Newcrom B is a mixed-mode analytical column with positively-charged basic ion-pairing groups at the terminal end of long ligand chains.

– Enhances retention of weak acidic compounds through anion-exchange mechanisms.
– Improves retention of multi-charged compounds.
– Separates bases using ion-exclusion mechanisms.
– Retains neutral compounds by reverse-phase mechanisms.
– Requires low buffer concentration for efficient ion-exchange.
– Offers compatibility with mobile phases selected for LC-MS, preparative chromatography, and low UV detection.