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Cyralis CL

  • Description
  • Purchase
  • Applications
Column Diameter

2.1 mm, 3.2 mm, 4.6 mm
Column Length

50 mm, 100 mm, 150 mm, 250 mm, Guard
Particle Size

3 µm, 5 µm, 10 µm
Pore Size

100 A
Brand

SIELC Technologies
Column options

Normal phase, Reversed Phase

Cyralis CL is a new column from SIELC Technologies

Cyralis CL is a new column from SIELC Technologies designed for chiral chromatography. It consists of a polysaccharide selector, cellulose tris(3-chloro-4-methylphenylcarbamate), coated onto silica. It separates racemates by using the polysaccharide selector to induce subtle energetic differences between enantiomers and the selector as they flow through and interact with the stationary phase.The column can be used to separate chiral neutral compounds, acids, bases and chiral salts.
This coated column can be used in normal phase conditions of alkane/alcohol mixtures, polar organic mode (alcohol/MeCN mixtures) or reverse phase conditions. The column is sold in all standard column dimensions (50, 100, 150 and 250 mm) and particle sizes (3, 5 and 10 μm).
Benefits

The column is usable across all four of the major chromatographic modes: NP, RP, HILIC and PO
The column is able to resolve not only enantiomeric pairs but complex stereoisomeric mixtures of molecules with multiple stereocenters
Expand capabilities – The polysaccharide selector is sensitive to temperature changes, enabling temperature tuning in chiral methods
Future-ready – The stationary phase tolerates relatively high additive percentages

Key Benefits:

  • ✓
    All-in-One Performance – RP, HILIC, ion-exchange, ion-exclusion, and normal phase in a single column.
  • ✓
    Dynamic Adaptation – Surface chemistry responds to solvent composition, buffer, pH, and ionic strength.
  • ✓
    Tunable Selectivity – Fine-tune separations with small adjustments in organic content, salt, or pH.
  • ✓
    Single-Phase Advantage – No mixed packing or phase separation; ensures reproducible results and robust performance.
  • ✓
    Versatile Compatibility – Works with aqueous-organic systems, pure organic solvents, and common mobile phase additives.
  • ✓
    Trace-Level Sensitivity – Exceptionally low bleed, suitable for LC-MS and advanced detection methods.

How It Works?

Chromni™’s stationary phase integrates in a single ligand hydrophobic, polar, and ionizable functionalities in a carefully balanced chemistry. This allows one column to switch between separation modes simply by adjusting the mobile phase:

  • Aqueous-organic mobile phases → Hydrophobic retention (Reversed-phase)
  • High-organic conditions → Polar retention (HILIC)
  • Buffered ionic modifiers → Ion-exchange / Ion-exclusion
  • Pure organic solvents → Normal phase

The result is unprecedented flexibility and control, enabling laboratories to explore multiple retention mechanisms without changing columns.

Cyralis CM is a new column from SIELC Technologies designed for chiral chromatography.

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36-month financing with market rates is offered to companies, individuals, and educational institutions subject to credit approval. For more details please contact us at financing@sielc.com.