A New Standard in HPLC Column Connection by SIELC
SIELC Technologies, a pioneer in chromatography innovation, introduces a single-ended HPLC column — a revolutionary new design that redefines how columns are connected and used in high-performance liquid chromatography. For decades, laboratories have relied on the same standard column format — and have dealt with the same recurring problems: leaky fittings, clogged junctions, dead volume, and the constant hassle of tubing and connection selection.
SIELC has developed a single-ended HPLC column design. This new system redefines how columns are installed, used, and replaced — streamlining your workflow and eliminating common points of failure.
Key Benefits of the New Design:
Advantages of a Single-Ended HPLC Column

- No fittings or tubing required — eliminates leaks, complex installation, and the need to match tubing length or ID.
- Zero dead volume thanks to a direct connection via a dedicated adapter.
- Leak containment — in case of pressure failure, solvent remains inside the adapter with no external leakage.
- Tool-free column replacement — disconnect the column without touching the fittings.
- Aluminum body — ensures efficient heat transfer and provides a smooth, label-friendly surface even on the shortest columns.
How the Single-Ended HPLC Column Works?

Why This Matters
This new column system removes the guesswork and fragility from high-pressure liquid chromatography. By eliminating traditional high-pressure fittings and minimizing dead volume, you gain more consistent results, lower the risk of system failure, and reduce downtime. Whether you’re running routine analyses or complex separations, this design enhances reliability and usability — so you can focus on your science, not your setup.
All SIELC and Traditional Columns Available in a New Format
C18, HILIC, Ion Exchange, Mixed-Mode, Ion Exclusion, Protein, BIST, and more.