Cyralis™ Screening Kit
Ultrafast Chiral Screening.
Explore four polysaccharide stationary phases with 1.5 µm nonporous particles to identify promising chiral interactions faster.
Find Your Chiral Screening Hits Faster
Screening extensive libraries of new chiral compounds can take days with standard porous columns measuring 150 mm or longer. SIELC introduces 1.5 µm nonporous analogues of the Cyralis™ family, designed for ultrafast initial screening.
The goal is a rapid yes/no answer regarding interaction between an analyte and a chiral stationary phase (CSP). Screen an analyte across the four phases under a selected mobile-phase condition, then identify promising hits for further method development.
Why Nonporous Particles?
Nonporous particles have no internal pore surface. Analytes interact with the external surface without diffusing into and out of particle pores, reducing the contribution of intraparticle mass transfer to band broadening.
Resolution per Unit Time
The theoretical advantage is expressed as Rs/t: resolution per unit time. Nonporous particles are intended to improve this balance for rapid screening.
No Pore Diffusion
Eliminating diffusion within pores reduces a contribution to the mass-transfer term of the van Deemter equation.
The Capacity Trade-Off
The smaller available surface area reduces sample capacity. The intended application is initial chiral screening.
One Analyte. Four Phases. Identify the Hits.
Compare the analyte’s behavior across AM, CM, AL, and CL under the same selected mobile-phase condition.
1. Screen
Test the compound on each of the four nonporous Cyralis™ phases.
2. Compare
Review the chromatograms to identify phases showing promising chiral selectivity.
3. Follow Up
Use the screening hits to guide subsequent method development.
The chromatograms in the brochure illustrate this approach: one analyte screened against the Cyralis™ phases in a selected mobile phase, followed by identification of hits.
Explore the Cyralis™ Stationary Phases
Cellulose-Based Stationary Phase
Cyralis™ CM
Cellulose tris(3,5-dimethylphenylcarbamate)
Suitable for chiral neutral compounds, acids, bases, and chiral salts.
Amylose-Based Stationary Phase
Cyralis™ AM
Amylose tris(3,5-dimethylphenylcarbamate)
Suitable for chiral neutral compounds, acids, bases, and chiral salts.
Cellulose-Based Stationary Phase
Cyralis™ CL
Cellulose tris(3-chloro-4-methylphenylcarbamate)
Suitable for chiral neutral compounds, acids, bases, and chiral salts.
Amylose-Based Stationary Phase
Cyralis™ AL
Amylose tris(3-chloro-4-methylphenylcarbamate)
Suitable for chiral neutral compounds, acids, bases, and chiral salts.
What’s Included in the Kit?
Four columns sold together to screen compounds whose affinity for the individual polysaccharide phases is unknown.
Start with a Faster Screen.
Explore the Cyralis™ Screening Kit for your next chiral screening project.
