Primesep® mixed-mode stationary phases allow to simultaneously separate organic and inorganic compounds with the same HPLC method.
In many instances, ionizable compounds exist as a salt of organic molecule with inorganic counter ion.
It is common for drugs, surface active compounds, biological molecules, and many other industrial and research substances.
Typically, two independent analytical methods are created for the analysis of such salts — reverse-phase for the organic part, and ion-chromatography, or titration, for the inorganic part of the molecule.
Primesep® columns offer unique ability to analyze both parts of the salt at the same time. ELSD in combination with a standard UV detector is a convenient tool for detection of the salt components.