| CAS Number | 5138-18-1 |
|---|---|
| Molecular Formula | C4H6O7S |
| Molecular Weight | 198.150 |
| InChI Key | ULUAUXLGCMPNKK-UHFFFAOYSA-N |
| LogP | -1.66 |
| Synonyms |
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Applications:
HPLC Determination of Sulfosuccinic Acid on Newcrom BH Column
August 6, 2021
HPLC Method for Sulfosuccinic acid on Newcrom BH by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Sulfosuccinic Acid.
Sulfosuccinic acid is a surfactant with the chemical formula C4H6O7S. It is used as a dispersing agent in pesticides, herbicides, and pigments. In fertilizers, it is used as a complexing agent. It is also used to enhance solubility and bioavailability of drugs in oral dosages.
Sulfosuccinic acid can be retained on the Newcrom BH mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. The analysis method can be UV detected at 200 nm.
| Column | Newcrom BH, 3.2 x 100 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O -10/90% |
| Buffer | H2SO4 – 0.3% |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 200 nm |
| Class of Compounds |
Acid |
| Analyzing Compounds | Sulfosuccinic acid |
Application Column
Newcrom BH
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
The Separation of Sodium, Dioctylsulfosuccinic Acid, and Sulfosuccinic Acid
July 2, 2013
Sulfosuccinic acid and the corresponding dioctyl ester were separated on the Primesep B4 short carbon-chain anion-exchange column. Short carbon chain stationary phase allows to elute hydrophobic and acidic diester in reasonable time. No elution was observed on the mixed-mode columns with longer carbon chain analogs due to very strong hydrophobic and anion-exchange interaction.
| Column | Primesep B4, 3.2×50 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 10 -50%, 10 min |
| Buffer | Gradient AmFm pH 3.0- 60-180 mM, 10 min |
| Flow Rate | 1.0 ml/min |
| Detection | ELSD, 50C |
| Class of Compounds |
Acid, Hydrophilic, Ionizable |
| Analyzing Compounds | Sodium, Dioctyl Sulfosuccinic acid, Sodium Docusate |
Application Column
Primesep B4
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsSodium
Sulfosuccinic acid
HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid
July 10, 2012
Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent. It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.
Application Columns: Primesep B4
Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid
Detection technique: LC/MS, ELSD/CAD
| Column | Primesep B4, 3.2×50 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 10 -50%, 10 min |
| Buffer | Gradient AmFm pH 3.0- 60-180 mM, 10 min |
| Flow Rate | 1.0 ml/min |
| Detection | ELSD |
| Class of Compounds |
Acid, Hydrophilic, Ionizable |
| Analyzing Compounds | Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid |
Application Column
Primesep B2
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select options
Primesep B4
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select options
Primesep D
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsDocusate sodium
Sodium
Sulfosuccinic acid
HPLC Analysis of Sulfosuccinic Acid on a Primesep S Column
July 10, 2012
Application Notes: Sulfosuccinic acid was retained on Primesep S HILIC/anion exclusion Primesep S column. Retention time is controlled by the amount of ACN, buffer pH and buffer concentration. Since the compound has no UV activity ELSD was used for monitoring and quantitation.
Application Columns: Primesep S
Application compounds: Sulfosuccinic Acid
Detection technique: UV, LC/MS, ELSD/CAD
| Column | Primesep S, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN |
| Buffer | AmAc |
| Flow Rate | 1.0 ml/min |
| Detection | ELSD |
| Class of Compounds |
Acid, Hydrophilic, Ionizable |
| Analyzing Compounds | Sulfosuccinic Acid |
Application Column
Primesep S
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsUV Detection
