The Separation of Sodium, Dioctylsulfosuccinic Acid, and Sulfosuccinic Acid

  Sulfosuccinic acid and the corresponding dioctyl ester were separated on the Primesep B4 short carbon-chain anion-exchange column. Short carbon chain stationary phase allows to elute hydrophobic and acidic diester in reasonable time. No elution was observed on the mixed-mode columns with longer carbon chain analogs due to very strong hydrophobic and anion-exchange interaction.  


Column Primesep B4, 3.2x50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 10 -50%, 10 min
Buffer Gradient AmFm pH 3.0- 60-180 mM, 10 min
Flow Rate 1.0 ml/min
Detection ELSD, 50C


Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Sodium, Dioctyl Sulfosuccinic acid, Sodium Docusate
Application Analytes:
Dioctyl sulfosuccinic acid
Sulfosuccinic acid