| CAS Number | 10041-19-7 |
|---|---|
| Molecular Formula | C20H38O7S |
| Molecular Weight | 422.577 |
| InChI Key | HNSDLXPSAYFUHK-UHFFFAOYSA-N |
| LogP | 5.1 |
| Synonyms |
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Applications:
HPLC Determination of Docusate Sodium in Softgels on Newcrom BH Column
August 5, 2021
Separation type: Liquid Chromatography Mixed-mode
High Performance Liquid Chromatography (HPLC) Method for Analysis of Docusate.
Docusate is used as a laxative and stool softener. Docusate retains water in the stool, thereby acting as a stool softener to facilitate stool passage. Docusate can be retained on the Newcrom BH mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. The analysis method can be UV detected at 200 nm.
| Column | Newcrom BH, 3.2×100 mm, 3 µm, 100A |
| Mobile Phase | MeCN/H2O -75/25% |
| Buffer | H2SO4 – 0.5% |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 200 nm |
| Class of Compounds |
Drug |
| Analyzing Compounds | Docusate Sodium |
Application Column
Newcrom BH
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select optionsDocusate sodium
The Separation of Sodium, Dioctylsulfosuccinic Acid, and Sulfosuccinic Acid
July 2, 2013
Sulfosuccinic acid and the corresponding dioctyl ester were separated on the Primesep B4 short carbon-chain anion-exchange column. Short carbon chain stationary phase allows to elute hydrophobic and acidic diester in reasonable time. No elution was observed on the mixed-mode columns with longer carbon chain analogs due to very strong hydrophobic and anion-exchange interaction.
| Column | Primesep B4, 3.2×50 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 10 -50%, 10 min |
| Buffer | Gradient AmFm pH 3.0- 60-180 mM, 10 min |
| Flow Rate | 1.0 ml/min |
| Detection | ELSD, 50C |
| Class of Compounds |
Acid, Hydrophilic, Ionizable |
| Analyzing Compounds | Sodium, Dioctyl Sulfosuccinic acid, Sodium Docusate |
Application Column
Primesep B4
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsSodium
Sulfosuccinic acid
HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid
July 10, 2012
Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent. It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.
Application Columns: Primesep B4
Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid
Detection technique: LC/MS, ELSD/CAD
| Column | Primesep B4, 3.2×50 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 10 -50%, 10 min |
| Buffer | Gradient AmFm pH 3.0- 60-180 mM, 10 min |
| Flow Rate | 1.0 ml/min |
| Detection | ELSD |
| Class of Compounds |
Acid, Hydrophilic, Ionizable |
| Analyzing Compounds | Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid |
Application Column
Primesep B2
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select options
Primesep B4
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select options
Primesep D
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsDocusate sodium
Sodium
Sulfosuccinic acid
