Dioctyl sulfosuccinic acid

CAS Number10041-19-7
Molecular FormulaC20H38O7S
Molecular Weight422.577
InChI KeyHNSDLXPSAYFUHK-UHFFFAOYSA-N
LogP5.1
Synonyms
  • DOCUSATE
  • Docusate hydrogen
  • Docusate sodium
  • Dioctyl sulfosuccinic acid
  • Spolion 8
  • 1,4-Bis(2-ethylhexyl) sulfosuccinate
  • 10041-19-7
  • doss
  • EINECS 233-124-0
  • CHEBI:534
  • 1,4-Bis(2-ethylhexyl) 2-sulphosuccinate
  • Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
  • HNSDLXPSAYFUHK-UHFFFAOYSA-N
  • 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonic acid
  • Butanedionic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester
  • Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester
  • Doc-Q-Lace
  • DIOCTYL DISODIUM SULFOSUCCINATE
  • Dioctylsulfosuccinsaeure
  • 1-(2-Tolyl)ethanone
  • Bis(2-ethylhexyl)succinat-2-sulfonsaeure

Applications:

HPLC Determination of Docusate Sodium in Softgels on Newcrom BH Column

August 5, 2021

Separation type: Liquid Chromatography Mixed-mode


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High Performance Liquid Chromatography (HPLC) Method for Analysis of Docusate.

Docusate is used as a laxative and stool softener. Docusate retains water in the stool, thereby acting as a stool softener to facilitate stool passage. Docusate can be retained on the Newcrom BH mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. The analysis method can be UV detected at 200 nm.

Condition

Column Newcrom BH, 3.2×100 mm, 3 µm, 100A
Mobile Phase MeCN/H2O -75/25%
Buffer  H2SO4 – 0.5%
Flow Rate 0.5 ml/min
Detection UV, 200 nm

 

Description

Class of Compounds
Drug
Analyzing Compounds Docusate Sodium

 

Application Column

Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Dioctyl sulfosuccinic acid
Docusate sodium
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

The Separation of Sodium, Dioctylsulfosuccinic Acid, and Sulfosuccinic Acid

July 2, 2013

 

Sulfosuccinic acid and the corresponding dioctyl ester were separated on the Primesep B4 short carbon-chain anion-exchange column. Short carbon chain stationary phase allows to elute hydrophobic and acidic diester in reasonable time. No elution was observed on the mixed-mode columns with longer carbon chain analogs due to very strong hydrophobic and anion-exchange interaction.

 

Condition

Column Primesep B4, 3.2×50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10 -50%, 10 min
Buffer Gradient AmFm pH 3.0- 60-180 mM, 10 min
Flow Rate 1.0 ml/min
Detection ELSD, 50C

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Sodium, Dioctyl Sulfosuccinic acid, Sodium Docusate

 

Application Column

Primesep B4

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Dioctyl sulfosuccinic acid
Sodium
Sulfosuccinic acid

Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid

July 10, 2012

Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent.  It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.

 
Application Columns: Primesep B4

 
Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid

Detection technique: LC/MS, ELSD/CAD

Condition

Column Primesep B4, 3.2×50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10 -50%, 10 min
Buffer Gradient AmFm pH 3.0- 60-180 mM, 10 min
Flow Rate 1.0 ml/min
Detection ELSD

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid

 

Application Column

Primesep B2

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Primesep B4

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Primesep D

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Dioctyl sulfosuccinic acid
Docusate sodium
Sodium
Sulfosuccinic acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.