Methylparaben sodium

Methylparaben sodium structural formula

CAS Number5026-62-0
Molecular FormulaC8H7NaO3
Molecular Weight174.131
InChI KeyPESXGULMKCKJCC-UHFFFAOYSA-M
LogP1.24
Synonyms
  • Methylparaben sodium
  • Sodium 4-(methoxycarbonyl)phenolate
  • Benzoic acid, 4-hydroxy-, methyl ester, sodium salt (1:1)
  • 5026-62-0
  • Benzoic acid, 4-hydroxy-, methyl ester, sodium salt
  • 4-(Methoxycarbonyl)phenolate de sodium
  • 4-(metoxicarbonil)fenolato de sodio
  • 4-HYDROXYBENZOESAEURE-METHYLESTER-NA-SALZ
  • 4-Hydroxybenzoic acid methyl ester sodium salt
  • BENZOATE, 4-OXIDE-, METHYL, SODIUM
  • Benzoic acid, 4-hydroxy-, methyl ester, sodium salt (1:1)
  • Benzoic acid, p-hydroxy-, methyl ester, sodium salt
  • Bonomold OMNa
  • Methyl 4-hydroxybenzoate sodium salt
  • Methyl p-hydroxybenzoate sodium salt
  • Natrium-4-(methoxycarbonyl)phenolat
  • p-Hydroxybenzoic acid methyl ester sodium salt
  • Preserval MS
  • sodium 4-(methoxycarbonyl)phenolate
  • Sodium 4-(methoxycarbonyl)phenoxide
  • Sodium 4-carbomethoxyphenolate
  • Sodium methyl 4-hydroxybenzoate
  • Sodium methyl p-hydroxybenzoate
  • Sodium methyl-4-hydroxybenzoate
  • Sodium methylparaben
  • Sodium p-methoxycarbonylphenoxide
  • Sodium, (p-carboxyphenoxy)-, methyl ester
  • Solparol
  • EINECS 225-714-1
  • Methyl p-hydroxybenzoate, sodium salt
  • UNII-CR6K9C2NHK

Applications:

HPLC Analysis of Paraben Preservatives on Newcrom AH Column

October 29, 2020


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Condition

Column Newcrom AH, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer H2SO4 – 0.1%
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Preservatives,  Hydrophobic
Analyzing Compounds Methyl Paraben, Ethyl Paraben, Propyl Paraben

 

Application Column

Newcrom AH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ethylparaben
Methylparaben
Methylparaben sodium
Parabens
Propylparaben
Propylparaben sodium
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of EDTA, Phenoxyethanol and Methylparaben in Facial Cleanser on Newcrom BH

August 25, 2020


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Condition

Column Newcrom BH, 4.6×150 mm,  100A
Mobile Phase Gradient MeCN – 2- 70%, 10 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV 260nm

Description

Class of Compounds Acid, Hydrophilic, Preservatives
Analyzing Compounds EDTA, Methylparaben, Phenoxyethanol

 

Application Column

Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
2-Phenoxyethanol
EDTA (Ethylenediaminetetraacetic Acid)
Methylparaben
Methylparaben sodium
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Mixture of Carbocisteine, Methylparaben & Propylparaben on Primesep 100 Column

July 31, 2019


Carbocysteine is a medication that reduces the viscosity of mucus making it easier to cough up. Methylparaben and propylparaben are used as preservatives in cosmetics, pharmaceuticals and food. They can be separated in HPLC on a Primesep 100 mixed-mode column by both hydrophobic and ionic properties present on the stationary phase. The analytical method uses acetonitrile (ACN) gradient and water with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.

Condition

Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN  – 2-50%, 20 min
Buffer H2SO4 – 0.05 %
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description

Class of Compounds
Drug,  Acid, Hydrophilic, Ionizable, Carboxylic acid, Carbocyclic, Benzoate, Hydroxy Acid, Amino Acid, Hydroxybenzoate, Phenol
Analyzing Compounds Carbocisteine, Methylparaben, Propylparaben

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Carbocisteine
Methylparaben
Methylparaben sodium
Propylparaben
Propylparaben sodium
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Methylparaben sodium on Newcrom R1 HPLC column

February 16, 2018
Separation of Methylparaben sodium on Newcrom C18 HPLC column

Methylparaben sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Methylparaben sodium
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.