| CAS Number | 638-23-3 |
|---|---|
| Molecular Formula | C5H9NO4S |
| Molecular Weight | 179.2 |
| InChI Key | GBFLZEXEOZUWRN-VKHMYHEASA-N |
| LogP | -3.1 |
| Synonyms |
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Applications:
HPLC Separation of Mixture of Carbocisteine, Methylparaben & Propylparaben on Primesep 100 Column
July 31, 2019
Carbocysteine is a medication that reduces the viscosity of mucus making it easier to cough up. Methylparaben and propylparaben are used as preservatives in cosmetics, pharmaceuticals and food. They can be separated in HPLC on a Primesep 100 mixed-mode column by both hydrophobic and ionic properties present on the stationary phase. The analytical method uses acetonitrile (ACN) gradient and water with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.
| Column | Primesep 100, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 2-50%, 20 min |
| Buffer | H2SO4 – 0.05 % |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 200 nm |
| Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, Carboxylic acid, Carbocyclic, Benzoate, Hydroxy Acid, Amino Acid, Hydroxybenzoate, Phenol |
| Analyzing Compounds | Carbocisteine, Methylparaben, Propylparaben |
Application Column
Primesep 100
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsMethylparaben
Methylparaben sodium
Propylparaben
Propylparaben sodium
HPLC Determination of Carbocisteine on Primesep 100 Column
July 31, 2019
Carbocisteine, or carbocysteine, is a drug designed to clear the mucus from the upper and lower airways. It’s primarily available in tablet form. It can be retained on a Primesep 100 Column in about 5 minutes. Primesep 100 is a reverse-phase (RP) mixed-mode column with embedded acidic ion-pairing groups.
Condition
Column Primesep 100, 4.6×150 mm, 5 µm, 100A Mobile Phase MeCN/H2O – 10/90% Buffer H2SO4 – 0.05 % Flow Rate 1.0 ml/min Detection UV, 200 nm
Description
Class of Compounds
Acid, Hydrophilic, Ionizable, Carboxylic acid, Drug, Carbocyclic, Amino acid Analyzing Compounds Carbocisteine
Application Column
Primesep 100
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsS-(Carboxymethyl)-L-cysteine
