Tartaric Acid

Tartaric Acid structural formula

CAS Number87-69-4
Molecular FormulaC4H6O6
Molecular Weight150.086
InChI KeyFEWJPZIEWOKRBE-JCYAYHJZSA-N
LogP-1.47
Synonyms
  • L-Tartaric acid
  • (2R,3R)-2,3-Dihydroxybutanedioic acid
  • Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-
  • 87-69-4
  • L-(+)-Tartaric acid
  • Butanedioic acid, 2,3-dihydroxy- (2R,3R)-
  • (+)-(2R,3R)-Tartaric acid
  • (+)-(R,R)-Tartaric acid
  • (+)-L-Tartaric acid
  • (+)-tartaric acid
  • (+)-Weinsaure
  • (2R,3R)-(+)-Tartaric acid
  • (2R,3R)-2,3-Dihydroxysuccinic acid
  • (2R,3R)-Tartaric acid
  • (R,R)-(+)-Tartaric acid
  • (R,R)-Tartaric acid
  • 1,2-Dihydroxyethane-1,2-dicarboxylic acid
  • 2,3-Dihydroxybutanedioic acid
  • 2R,3R-Tartaric acid
  • Acide (+)-tartrique
  • acido (+)-tartarico
  • BUTANEDIOIC ACID, 2,3-DIHYDROXY-
  • Butanedioic acid, 2,3-dihydroxy- [R-(R*,R*)]-
  • Butanedioic acid, 2,3-dihydroxy-, [R-(R*,R*)]-
  • Butanedioic acid, 2,3-dihydroxy-[R-(R*,R*)]-
  • Dextrotartaric acid
  • DIHYDROXY BUTANEDIOIC ACID
  • Dihydroxysuccinic acid
  • d-α,β-Dihydroxysuccinic acid
  • Natural tartaric acid
  • NSC 62778
  • Succinic acid, 2,3-dihydroxy
  • TARTARIC ACID
  • Tartaric Acid AR (1LB/BT)
  • Tartaric acid, L-(+)-
  • Threaric acid
  • WEINSAEURE
  • d-alpha,beta-Dihydroxysuccinic acid
  • EINECS 201-766-0
  • Kyselina 2,3-dihydroxybutandiova
  • Kyselina vinna
  • UNII-W4888I119H
  • (+)-Weinsaeure
  • (+)-tartarate
  • (1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid
  • (2R,3R)-2,3-Dihydroxybernsteinsaeure
  • (2R,3R)-2,3-dihydroxybutanedioate
  • (2R,3R)-2,3-tartaric acid
  • (2R,3R)-Tartarate
  • (R,R)-tartarate
  • (R,R)-tartaric acid
  • 2,3-Dihydroxy-succinate
  • 2,3-Dihydroxy-succinic acid
  • 2,3-Dihydroxybutanedioate
  • 2,3-Dihydroxysuccinic acid
  • D-Tartaric acid
  • D-a,b-Dihydroxysuccinic acid
  • L(+)-Tartaric acid
  • L-Tartarate
  • L-threaric acid
  • Rechtsweinsaeure
  • TAR
  • TLA
  • Tartarate
  • Weinsteinsaeure
  • 1039646-76-8
  • 1336-18-1
  • 8014-54-8
  • 8059-77-6
  • 1334703-49-9

Applications:

HPLC Separation of Tartaric Acid and Citric Acids on Newcrom BH Column

March 22, 2021


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Condition

Column Newcrom BH, 4.6×150 mm, 3 µm, 100A
Mobile Phase H2O
Buffer H3PO4
Flow Rate 1.0 ml/min
Detection UV 200 nm

Description

Class of Compounds Acid, Hydrophilic
Analyzing Compounds Tartaric Acid, Citric Acid

Application Column

Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Citric Acid
Tartaric Acid
dl-Tartaric acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Determination of Tartaric Acid on Newcrom BH Column

February 5, 2020

HPLC Method for Analysis of Tartaric Acid on Newcrom BH by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode
HPLC Determination of Tartaric Acid on Newcrom BH Column

Tartaric acid is a naturally occurring organic acid that is found in many plants, particularly in grapes and tamarinds. It’s known for its sour taste and antioxidant properties. Chemically, tartaric acid is a white, crystalline organic acid. It has the chemical formula C4H6O6.

Tartaric acid has been used in winemaking for centuries because it plays a key role in the fermentation process. It’s also used in baking powder, where it serves as a leavening agent.

In addition to these culinary uses, tartaric acid is used in the manufacturing of effervescent salts, in combination with citric acid, to improve taste and make a fizz. It’s also found in some of the very effective rust removal and cleaning solutions.

Tartaric acid is used in cream of tartar (potassium bitartrate), which is used in cooking and baking. It can also be found in a variety of other foods, including soft drinks, fruit juices, candies, and ice cream.

Like other acids, tartaric acid can be hazardous in large quantities, and it should always be handled and stored appropriately. Always refer to the safety data sheet for this substance and follow the recommended safety guidelines.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Tartaric Acid

Condition

ColumnNewcrom BH, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 20/80%
BufferH3PO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 200 nm
Class of CompoundsAcid, Hydrophilic
Analyzing CompoundsTartaric Acid

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Tartaric Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Small Organic Acids on Newcrom B Column

October 22, 2019


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Condition

Column Newcrom B, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 5/95%
Buffer AmAc pH 5.0, Formic Acid
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase

Description

Class of Compounds Acid, Hydrophilic, Ionizable
Analyzing Compounds Glycolic acid, Succinic Acid, Methylmalonic acid, Malic Acid, Maleic Acid, Citric Acid, Tartaric Acid, Fumaric Acid, Malonic Acid

Application Column

Newcrom B

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Citric Acid
Fumaric Acid
Gluconic acid
Glycolic acid
Maleic Acid
Malic Acid
Malonic Acid
Methylmalonic Acid
Succinic Acid
Tartaric Acid
dl-Tartaric acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Analysis of Basic Drugs and Acidic Counter-Ions by Mixed-Mode Chromatography

July 16, 2009

The majority of drugs in the pharmaceutical industry are administered in salt form. The presence of two counter-ions very often necessitates the use of two methods. The nature of these counterparts in drugs can be an inorganic cation and organic acid, inorganic anion and organic base, and organic cation and organic anion. Furthermore, the properties of the molecules will result in a differing stoichiometry. The task of simultaneous quantitation of counter-ions can be achieved by using mixed-mode columns. The general approach for analysis is based on properties of corresponding counter-ions. Hydrophobic basic drugs, like dextromethorphan, verapamil, trimipramine, and corresponding acidic counter-ions (chloride, chlorate, bromide, bromate, perchlorate, maleate, fumarate,tartrate, succinate, phosphate, citrate, benzosulfonate, toleuensulfonate) can be separated and quantitated in the same run on reversed-phase anion-exchange column. Basic hydrophobic drugs are retained by the reversed-phase mechanism, and counter-ions are retained by the reversed-phase and anion-exchange mechanism. Some polar counter-ions are retained only by the anion-exchange mechanism. Retention time and selectivity of HPLC separation of drugs and counter-ions can be achieved by changing the amount of acetonitrile and the amount of ions in the mobile phase. The detection technique depends on the properties of the counter-ions. In case of low or no UV activity, ELSD can be employed if the counter-ion forms a non-volatile salt with the mobile phase additive (ammonium formate). This HPLC method can be used for simultaneous quantitation of other basic drugs and counter-ions. The presence of two mechanisms of retention allows control over retention times of drug and counter-ion independently, and even allows a change of order of elution when necessary.

Condition

Column Primesep D , 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer AmFm pH 3.0
Flow Rate 1.0 ml/min
Detection ELSD, UV 270

Description

Class of Compounds Ions, Hydrophilic, Hydrophobic, Base, Acids, Ionizable
Analyzing Compounds Sodium Chloride, Sodium chloride, Sodium Chlorate, Sodium bromide, Sodium bromate, Perchloric Acid, Maleic Acid, Fumaric Acid, Tartaric Acid, Succinic Acid, Phosphoric Acid, Citric acid, Benzosulfonic acid,  Dextromethorphan, Verapamil, Trimipramine

Application Column

Primesep D

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Benzenesulfonic Acid
Bromide
Chlorate
Chloride
Citric Acid
Dextromethorphan
Fumaric Acid
Maleic Acid
Organic Acids
Perchlorate
Phosphoric Acid
Pyrilamine
Succinic Acid
Tartaric Acid
Verapamil
p-Toluenesulfonic Acid (PTSA)

Application Detection:
ELSD Detection
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HILIC Separation of Carboxylic Acids

August 22, 2008

Hydrophilic acids are separated on Obelisc N mixed-mode HILIC column. Seven carboxylic acids are separated based on their polarity and pKa values. Changes in ionization states of acids and stationary phase can be used to control elution order of organic and inorganic acids.

Application Column

Obelisc N

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

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Application Analytes:
Fumaric Acid
Hydroxybenzoic Acid
Malic Acid
Mandelic Acid
Methylmalonic Acid
Organic Acids
Succinic Acid
Tartaric Acid

Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.