Mandelic Acid

Mandelic Acid structural formula

CAS Number90-64-2
Molecular FormulaC8H8O3
Molecular Weight152.149
InChI KeyIWYDHOAUDWTVEP-UHFFFAOYSA-N
LogP0.62
Synonyms
  • Mandelic acid
  • Hydroxy(phenyl)acetic acid
  • Benzeneacetic acid, alpha-hydroxy-
  • 90-64-2
  • Benzeneacetic acid, alpha-hydroxy-
  • (+/-)-2-Hydroxy-2-phenylethanoic acid
  • (+/-)-Mandelic acid
  • (+/-)-alpha-Hydroxybenzeneacetic acid
  • (+/-)-alpha-Hydroxyphenylacetic acid
  • (RS)-Mandelic acid
  • 2-Hydroxy-2-phenylacetic acid
  • 2-Phenyl-2-hydroxyacetic acid
  • 2-Phenylglycolic acid
  • Acide mandelique
  • acido mandelico
  • Almond acid
  • alpha-Hydroxy-Phenylacetic acid
  • Amygdalic acid
  • D,L-MANDELSAEURE
  • DL-Amygdalic acid
  • DL-Hydroxy(phenyl)acetic acid
  • dl-Mandelic acid
  • Mandelsaure
  • NSC 7925
  • Paramandelic acid
  • Phenylglycolic acid
  • Phenylhydroxyacetic acid
  • Uromaline
  • alpha-Hydroxybenzeneacetic acid
  • alpha-Hydroxybenzeneacetic acid, (.+-.)-
  • alpha-Hydroxyphenylacetic acid
  • alpha-Hydroxy-α-toluic acid
  • EINECS 202-007-6
  • EINECS 210-277-1
  • Glycolic acid, phenyl-
  • p-Mandelic acid
  • Racemic mandelic acid
  • alpha-Toluic acid, alpha-hydroxy-
  • 2-Hydroy-2-phenylacetic acid
  • Kyselina 2-fenyl-2-hydroxyethanova
  • Kyselina mandlova
  • UNII-NH496X0UJX
  • (2S)-2-hydroxy-2-phenylacetic acid
  • (RS)-Mandelate
  • 2-Hydroxy-2-phenylacetate
  • 2-Hydroxy-2-phenylethanoate
  • 2-Hydroxy-2-phenylethanoic acid
  • 2-Phenyl-2-hydroxyacetate
  • 2-Phenylglycolate
  • Amygdalate
  • DL-Amygdalate
  • DL-Hydroxy(phenyl)acetate
  • DL-Hydroxy(phenyl)acetic acid
  • DL-Mandelate
  • Mandelate
  • Paramandelate
  • Phenylglycolate
  • Phenylhydroxyacetate
  • a-Hydroxy-a-toluate
  • a-Hydroxy-a-toluic acid
  • a-Hydroxybenzeneacetate
  • a-Hydroxybenzeneacetic acid
  • a-Hydroxyphenylacetate
  • a-Hydroxyphenylacetic acid
  • alpha-Hydroxy-alpha-toluate
  • alpha-Hydroxy-alpha-toluic acid
  • alpha-Hydroxybenzeneacetate
  • alpha-Hydroxyphenylacetate
  • 15769-78-5
  • 611-72-3
  • 71036-61-8

Applications:

HILIC Separation of Carboxylic Acids

2008-08-22

Hydrophilic acids are separated on Obelisc N mixed-mode HILIC column. Seven carboxylic acids are separated based on their polarity and pKa values. Changes in ionization states of acids and stationary phase can be used to control elution order of organic and inorganic acids.

Application Column

Obelisc N

SIELC has developed the mixed-mode Obelisc™ columns to be the first commercially available columns with Liquid Separation Cell technology (LiSC™). This cost effective duo can replace multiple HPLC columns such as reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion- exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters  - Buffer concentration, Buffer pH, and Organic Modifier Concentration  - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options
Application Analytes:
Fumaric Acid
Hydroxybenzoic Acid
Malic Acid
Mandelic Acid
Methylmalonic Acid
Organic Acids
Succinic Acid
Tartaric Acid
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Complex Mixture of Acids, Bases, Amino Acids, and Neutral Compounds

2006-10-14

Primesep 100 separates a mixture of amino acids (tyrosine, phenylalanine), organic acids (benzoic acid, mandelic acid), amines (benzylamine, pyridine), and neutrals (benzonitrile, toluene) in one HPLC run by combining reversed-phase, cation-exchange, and polar interactions. The method is tunable and peak order can be changed significantly by adjusting acetonitrile and trifluoroacetic acid concentrations. The separation method uses a mobile phase mixture of water, acetonitrile (MeCN, ACN) and trifluoracetic acid (TFA) and compatible with UV, mass spec (LC/MS) and evaporative light scattering (ELSD) detection.

Condition
Column Primesep 100, 4.6×250 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer TFA – 0.2
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description
Class of Compounds
 Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds Tyrosine, phenylalanine, Benzoic acid, mandelic acid, Benzylamine, Pyridine, Benzonitrile, Toluene

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offer a wide variety of stationary phases with an unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications. Corresponding Primesep guard columns are available with all stationary phases and do not require holders. SIELC offers a method development service which is available for all customers. Ask about our special custom LC-phases tailored for specific separations.

Select options
Application Analytes:
Amino Acids
Benzoic Acid
Benzonitrile
Benzylamine
Mandelic Acid
Organic Acids
Phenylalanine
Pyridine
Toluene
Tyrosine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.