Trimellitic Acid

Molecular FormulaC9H6O6
Molecular Weight210.14
InChI KeyARCGXLSVLAOJQL-UHFFFAOYSA-N
LogP0.3
Synonyms
  • 1,2,4-Benzenetricarboxylic acid
  • 528-44-9
  • TRIMELLITIC ACID
  • Benzene-1,2,4-tricarboxylic acid
  • 1,2,4-Tricarboxybenzene
  • 4-Carboxyphthalic acid
  • 1,3,4-Benzenetricarboxylic acid
  • 1,4,5-Benzenetricarboxylic acid
  • UNII-7NVY29MQ5F
  • 7NVY29MQ5F
  • CHEBI:166055
  • MFCD00002470
  • DSSTox_CID_1487
  • DSSTox_RID_76181
  • DSSTox_GSID_21487
  • 1,2,4-Benzenetricarboxylicacid
  • CAS-528-44-9
  • EINECS 208-432-3
  • NSC 72986
  • BRN 2214815
  • GHM
  • 1,4-Tricarboxybenzene
  • WLN: QVR BVQ DVQ
  • SCHEMBL23861
  • 4-09-00-03746 (Beilstein Handbook Reference)
  • 1,4-Benzenetricarboxylic acid
  • CHEMBL296024
  • DTXSID3021487
  • HMS1668A11
  • ZINC105301
  • ACT06811
  • AMY13397
  • NSC72986
  • Tox21_201939
  • Tox21_302990
  • AC2198
  • BBL011593
  • NSC-72986
  • STL163328
  • AKOS005716310
  • CCG-245088
  • CS-W015125
  • LS10175
  • MCULE-7395677755
  • NCGC00164021-01
  • NCGC00164021-02
  • NCGC00256331-01
  • NCGC00259488-01
  • AC-12673
  • AS-17898
  • SY010192
  • 1,2,4-Benzenetricarboxylic acid, >=99%
  • DB-071592
  • B0042

Applications:

UV-Vis Absorption Spectrum of Trimellitic Acid

December 12, 2025
Access the UV-Vis Spectrum SIELC Library
UV-Vis Spectrum of Trimellitic Acid.

If you are looking for optimized HPLC method to analyze Trimellitic Acid check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Trimellitic Acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Trimellitic Acid on Newcrom BH Column on Alltesta™

December 1, 2025

HPLC Method for Trimellitic Acid on Newcrom BH by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Trimellitic Acid 

Trimellitic Acid is an isomer of benzenetricarboxylic acid with the chemical formula C9H6O6. It is primarily used as carboxylate ligand in the synthesis of a wide range of metal-organic frameworks (MOFs).

Trimellitic Acid can be retained and analyzed using the Newcrom BH stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with sulfuric acid as a buffer. Detection is performed using UV.

Column Newcrom BH, 4.6 x 150 mm, 3 µm, 100 A, dual ended
Mobile Phase MeCN – 10%
Buffer Sulfuric Acid
Flow Rate 1.0 mL/min
Detection UV 275 nm
Class of Compounds Acid
Analyzing Compounds Trimellitic Acid

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Trimellitic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Mellitic Acid and Trimellitic Acid on Newcrom BH Column

March 6, 2024

HPLC Method for Analysis of Mellitic acid, Trimellitic Acid on Newcrom BH Column by SIELC Technologies

Separation type: Liquid Chromatography Reversed-phase

HPLC Method for Analysis of Mellitic Acid and Trimellitic Acid on Newcrom BH Column
HPLC Method for Analysis of Mellitic acid, Trimellitic Acid on Newcrom BH Column by SIELC Technologies

Mellitic Acid is an aromatic dicarboxylic acid with the chemical formula C12H6O12. It is a white crystalline solid and is derived from benzoic acid. Mellitic acid is named after mellite, a mineral in which it was first discovered. It is not commonly encountered in everyday use and does not have widespread applications.

Mellitic acid is mainly of interest in the fields of chemistry and mineralogy, and its practical applications are limited compared to other acids.

Trimellitic acid is a tricarboxylic acid with the chemical formula C9H6O6. It is also known as benzene-1,2,4-tricarboxylic acid. Trimellitic acid is used in various industrial applications, including the production of certain polymers and resins. It has three carboxylic acid functional groups, making it a useful building block in the synthesis of materials such as trimellitic anhydride (TMA), which is commonly employed in the manufacture of high-performance plastics. The unique structure and properties of trimellitic acid contribute to its role in specific chemical processes and the creation of specialized materials.

Mellitic acid and trimellitic acid can be retained, separated and analyzed on a reversed-phase Newcrom BH column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid. This analytical method can be detected with high resolution and peak symmetry at a wavelength of 220 nm using UV detection

High Performance Liquid Chromatography (HPLC) Method for Analyses of Mellitic acid, Trimellitic Acid on Newcrom BH Column by SIELC Technologies

Condition

ColumnNewcrom BH, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O
BufferH2SO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 220 nm
Injection volume:2 µL
Sample0.1 mg/ml
Sample DiluentH2O – 100%

Description

Class of CompoundsAcid
Analyzing CompoundsMellitic acid, Trimellitic Acid

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Mellitic acid
Trimellitic Acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Trimellitic Anhydride and Trimellitic Acid on Newcrom B Column

July 29, 2022

HPLC Method for Trimellitic anhydride, Trimellitic Acid on Newcrom B by SIELC Technologies

HPLC Method for Analysis of Trimellitic Anhydride and Trimellitic Acid on Newcrom B Column_1471

High Performance Liquid Chromatography (HPLC) Method for Analysis of Trimellitic anhydride, Trimellitic Acid.

Trimellitic anhydride is a trifunctional, highly reactive aromatic anhydride with the chemical formula C9H4O5. It is used as a curing agent for epoxy and other resins; in vinyl plasticizers, paints, coatings, dyes, pigments and a wide variety of other manufactured products. It is a common precursor to plasticizers for polyvinyl chloride (PVC). In acidic water, Trimellitic Anhydride will ‘open up’ back into Trimellitic Acid.

Trimellitic Acid is an isomer of benzenetricarboxylic acid with the chemical formula C9H6O6. It is primarily used as carboxylate ligand in the synthesis of a wide range of metal-organic frameworks (MOFs).

Trimellitic anhydride, Trimellitic Acid can be separated, retained, and analyzed on a mixed-mode Newcrom B column with a mobile phase consisting of water, Acetonitrile (MeCN), and Formic acid (FA). This analytical method can be UV detected at 250 nm or via negatively-charged Electrospray Ionization (ESI-) with high resolution and peak symmetry.

Condition

Column Newcrom B, 4.6 x 150 mm, 3 µm, 100 A, dual ended
Mobile Phase MeCN/H2O -50/50%
Buffer Formic Acid- 1.0%
Flow Rate 1.0 ml/min
Detection UV 250 nm, ESI

Description

Class of Compounds Acid, Hydrophilic
Analyzing Compounds Trimellitic anhydride, Trimellitic Acid

 

Application Column

Newcrom B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Trimellitic Acid
Trimellitic anhydride

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.