| CAS Number | 552-30-7 |
|---|---|
| Molecular Formula | C9H4O5 |
| Molecular Weight | 192.127 |
| InChI Key | SRPWOOOHEPICQU-UHFFFAOYSA-N |
| LogP | 1.05 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Trimellitic Anhydride and Trimellitic Acid on Newcrom B Column
July 29, 2022
Separation type: Liquid Chromatography Mixed-mode
High Performance Liquid Chromatography (HPLC) Method for Analysis of Trimellitic Anhydride and Trimellitic Acid
Trimellitic Anhydride is a common precursor to plasticizers for polyvinyl chloride (PVC); it’s acid form is Trimellitic Acid. In acidic water, Trimellitic Anhydride will ‘open up’ back into Trimellitic Acid. Trimellitic Anhydride and Trimellitic Acid can be separated, retained, and analyzed on a mixed-mode Newcrom B column with a mobile phase consisting of water, Acetonitrile (MeCN), and Formic acid (FA). This analytical method can be UV detected at 250 nm or via negatively-charged Electrospray Ionization (ESI-) with high resolution and peak symmetry.
| Column | Newcrom B, 4.6×150 mm, 100A |
| Mobile Phase | MeCN/H2O -50/50% |
| Buffer | Formic Acid- 1.0% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 250 nm, ESI |
| Class of Compounds | Acid, Hydrophilic |
| Analyzing Compounds | Trimellitic Anhydride and Trimellitic Acid |
Application Column
Newcrom B
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select optionsTrimellitic anhydride
HPLC Determination of Trimellitic anhydride on Newcrom BH
February 8, 2021
Separation type: Liquid Chromatography Mixed-mode
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High Performance Liquid Chromatography (HPLC) Method of Trimellitic anhydride.
Trimellitic anhydride is a trifunctional, highly reactive aromatic anhydride. It is used as a curing agent for epoxy and other resins; in vinyl plasticizers, paints, coatings, dyes, pigments and a wide variety of other manufactured products. Trimellitic Anhydride can be retained in HPLC with a Newcrom BH mixed-mode column using a mobile phase of acetonitrile (ACN) and water and Sulfuric Acid (H2SO4) buffer allowing the use of a UV detector at 210 nm.
| Column | Newcrom BH, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 5/95% |
| Buffer | H2SO4 – 0.2% |
| Flow Rate | 0.5 ml/min |
| Detection | 210 nm |
| Class of Compounds | Anhydride, Hidrophobic |
| Analyzing Compounds | Trimellitic anhydride |
Application Column
Newcrom BH
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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Separation of Trimellitic anhydride on Newcrom R1 HPLC column
February 19, 2018
Trimellitic anhydride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select options