Oseltamivir

CAS Number196618-13-0
Molecular FormulaC16H28N2O4
Molecular Weight312.4
InChI KeyVSZGPKBBMSAYNT-RRFJBIMHSA-N
LogP1.1
Synonyms
  • oseltamivir
  • 196618-13-0
  • Tamvir
  • Tamiflu-Free
  • GS-4104
  • (-)-oseltamivir
  • GS 4104
  • HSDB 7433
  • UNII-20O93L6F9H
  • Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
  • GOP-A-Flu
  • ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate
  • GS4104
  • Ro-64-0796
  • CHEBI:7798
  • 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))-
  • 20O93L6F9H
  • (3R,4R,5S)-Ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
  • Ro 640796
  • ebilfumin
  • Oseltamivir [INN:BAN]
  • oseltamivirum
  • Agucort
  • ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
  • Agucort (TN)
  • Oseltamivir (INN)
  • Tamiflu (*Phosphate salt 1:1*)
  • SR-05000001499
  • Ro-640796
  • CHEMBL1229
  • SCHEMBL32035
  • BIDD:GT0426
  • BDBM5025
  • GS-4071 ETHYL ESTER
  • DTXSID9044291
  • HMS2090C11
  • EX-A3415
  • ZINC3929508
  • CO0039
  • AKOS015843442
  • AKOS015960501
  • CS-0552
  • DB00198
  • DT-0013
  • MCULE-1441617774
  • (3R,5S)-ETHYL 4-ACETAMIDO-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENECARBOXYLATE
  • ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)cyclohexene-1-carboxylate
  • ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
  • Ethyl (5S,3R,4R)-4-(acetylamino)-5-amino-3-(ethylpropoxy)cyclohex-1-enecarboxylate
  • NCGC00095191-12
  • NCGC00178698-01
  • NCGC00178698-02
  • NCGC00178698-04
  • 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R,4R,5S)-
  • HY-13317
  • Oseltamivir 100 microg/mL in Acetonitrile
  • RO64-0796
  • C08092
  • D08306
  • W-5250
  • AB00173476-02
  • AB00173476_04
  • 618O130
  • AR-270/43507961
  • Q211509
  • SR-05000001499-1
  • BRD-K76011241-045-01-5
  • (3R,5S)-ethyl4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
  • Ethyl (3R, 4R, 5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
  • ethyl 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
  • (3r,4r,5s)-4-acetylamino-5-amino-3(1-ethylpropoxy) -1-cyclohexene-1-carboxylic acid ethyl ester
  • (3R,4R,5S)-4-acetylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Applications:

HPLC Separation of Antiviral Drugs on Primesep 100 Column

April 1, 2021

 HPLC Method for Acyclovir, Valacyclovir, Oseltamivir on Primesep 100 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Acyclovir, Valacyclovir, Oseltamivir.

Unlike antibiotic drugs, which actively destroy their targets, antiviral drugs generally prevent the reproduction of their viral targets. Acyclovir, Valacyclovir, and Oseltamivir are 3 antiviral drugs commonly prescribed to treat viral infections. Acyclovir and Valacyclovir are used to treat viral infections caused by a group of viruses called herpes simplex viruses. These infections include oral and genital herpes, as well as shingles. They can also be used to treat chickenpox in children. Oseltamivir is generally used to help treat (or if taken early enough, prevent) influenza (the flu) infections.
Acyclovir, Valacyclovir, Oseltamivir can be retained on a Primesep 100 mixed-mode column with great peak shape using acetonitrile (ACN), water and a gradient of sulphuric acid (H2SO4) as a buffer. This method can be UV detected at 200 nm with very high resolution.

Condition
Column Primesep 100, 3.2 x 100 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 30/70%
Buffer Gradient H2SO4 – 0.05- 0.8%, 10 min
Flow Rate 0.5 ml/min
Detection UV, 255 nm

 

Description
Class of Compounds
 Drug
Analyzing Compounds Acyclovir, Valacyclovir, Oseltamivir

 

Application Column

Primesep 100

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Acyclovir
Oseltamivir
Valacyclovir
Application Detection:
UV Detection
Vis Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of Oseltamivir on Primesep 100 Column

March 31, 2021

HPLC Method for Oseltamivir on Primesep 100 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Oseltamivir.

Oseltamivir belongs to a class of drugs called antivirals, which are used to treat infections caused by viruses. It is used in the treatment of the infection caused by the flu virus (influenza A and influenza B) and may also be used to prevent and treat swine influenza A.  It is recommended that it be used within the first 48 hours of the infection’s symptoms. It has the chemical formula C16H28N2O4.

Oseltamivir can be retained on a Primesep 100 column with great peak shape using an isocratic method of acetonitrile (ACN), water and sulfuric acid (H2SO4) as a buffer. UV Detection 200nm.

Condition
Column Primesep 100, 3.2 x 100 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 30/70%
Buffer H2SO4 – 0.5%
Flow Rate 0.5 ml/min
Detection UV, 200 nm

 

Description
Class of Compounds
 Drug
Analyzing Compounds Oseltamivir

 

Application Column

Primesep 100

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Oseltamivir
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.