| CAS Number | 2628280-40-8 |
|---|---|
| Molecular Formula | C23H32F3N5O4 |
| Molecular Weight | 499.5 |
| InChI Key | LIENCHBZNNMNKG-OJFNHCPVSA-N |
| LogP | 2.2 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Nirmatrelvir in PAXLOVID™ (Nirmatrelvir Tablets) on Primesep P Column
June 15, 2022
HPLC Method for Nirmatrelvir on Primesep P by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir.
Nirmatrelvir is an antiviral medication with the chemical formula C23H32F3N5O4. It is a part of a medical combination used to treat COVID-19. It works through inhibiting 3C-like protease. From November 2021, Nirmatrelvir has been allowed to be manufactured and sold in over 95 countries to ensure greater access to the global population.
Nirmatrelvir can be retained and analyzed using the Primesep P stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN). Detection is performed using UV.
| Column | Primesep P, 3.2 x 100 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | Gradient MeCN – 10-90% |
| Buffer | No |
| Flow Rate | 0.5 ml/min |
| Detection | UV 210nm |
| Class of Compounds | Drug |
| Analyzing Compounds | Nirmatrelvir |
Application Column
Primesep P
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
HPLC Method for Analysis of Nirmatrelvir and Ritonavir in Paxlovid Tablets on Primesep P column
June 15, 2022
HPLC Method for Nirmatrelvir, Ritonavir on Primesep P by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir, Ritonavir.
Nirmatrelvir is an antiviral medication with the chemical formula C23H32F3N5O4. It is a part of a medical combination used to treat COVID-19. It works through inhibiting 3C-like protease. From November 2021, Nirmatrelvir has been allowed to be manufactured and sold in over 95 countries to ensure greater access to the global population.
Ritonavir is an antiretroviral medication with the chemical formula C37H48N6O5S2. When used alone, it is used to treat HIV/AIDS. In combination with other drugs, especially potease inhibitors, it is used to treat Hepatitis C and COVID-19.
Nirmatrelvir, Ritonavir can be retained and analyzed using the Primesep P stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a perchloric acid buffer. Detection is performed using UV.
| Column | Primesep P, 3.2 x 100 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | Gradient MeCN – 40-75% |
| Buffer | HClO4 – 0.5% |
| Flow Rate | 0.5 ml/min |
| Detection | UV 210nm |
| Class of Compounds | Drug |
| Analyzing Compounds | Nirmatrelvir, Ritonavir |
Application Column
Primesep P
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Ritonavir
HPLC Method for Analysis of Nirmatrelvir and Ritonavir in Paxlovid Tablets on Primesep 100 Column
May 5, 2022
HPLC Method for Ritonavir, Nirmatrelvir on Primesep 100 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Ritonavir, Nirmatrelvir.
Nirmatrelvir is an antiviral medication with the chemical formula C23H32F3N5O4. It is a part of a medical combination used to treat COVID-19. It works through inhibiting 3C-like protease. From November 2021, Nirmatrelvir has been allowed to be manufactured and sold in over 95 countries to ensure greater access to the global population.
Ritonavir is an antiretroviral medication with the chemical formula C37H48N6O5S2. When used alone, it is used to treat HIV/AIDS. In combination with other drugs, especially potease inhibitors, it is used to treat Hepatitis C and COVID-19.
Ritonavir, Nirmatrelvir can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a Sulfuric Acid buffer. Detection is performed using UV.
| Column | Primesep 100, 3.2 x 100 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | Gradient MeCN – 50-70% |
| Buffer | H2SO4 – 0.5% |
| Flow Rate | 0.5 ml/min |
| Detection | UV 210nm |
| Class of Compounds | Drug |
| Analyzing Compounds | Ritonavir, Nirmatrelvir |
Application Column
Primesep 100
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Ritonavir
