Nirmatrelvir

CAS Number2628280-40-8
Molecular FormulaC23H32F3N5O4
Molecular Weight499.5
InChI KeyLIENCHBZNNMNKG-OJFNHCPVSA-N
LogP2.2
Synonyms
  • 2628280-40-8
  • 7R9A5P7H32
  • Nirmatrelvir
  • Paxlovid
  • PF-07321332
  • PF07321332
  • UNII-7R9A5P7H32
  • (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • (1R,2S,5S)-N-((1S)-1-Cyano-2-((3S)-2-oxopyrrolidin-3-yl)ethyl)-6,6-dimethyl-3-(3-methyl-N-(trifluoroacetyl)-L-valyl)-3-azabicyclo(3.1.0)hexane-2-carboxamide
  • (1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • Nirmatrelvir [USAN]
  • science.abl4784, 6
  • PF07321332(nirmatrelvir)
  • CHEMBL4802135
  • GTPL11503
  • CHEBI:170007
  • BDBM496902
  • EX-A5024

Applications:

HPLC Method for Analysis of Nirmatrelvir in PAXLOVID™ (Nirmatrelvir Tablets) on Primesep P Column

June 15, 2022

Separation type: Liquid Chromatography Mixed-mode

High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir

Condition
Column Promesep P, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 10-90%
Buffer No
Flow Rate 0.5 ml/min
Detection UV 210nm

Description
Class of Compounds Drug
Analyzing Compounds Nirmatrelvir,

 

Application Column

Primesep P

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Nirmatrelvir
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Nirmatrelvir and Ritonavir in Paxlovid Tablets on Primesep P column

June 15, 2022

Separation type: Liquid Chromatography Mixed-mode

High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir and Ritonavir

Condition
Column Promesep P, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 40-75%
Buffer HClO4 – 0.5%
Flow Rate 0.5 ml/min
Detection UV 210nm

Description
Class of Compounds Drug
Analyzing Compounds Nirmatrelvir,  Ritonavir

 

Application Column

Primesep P

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Nirmatrelvir
Ritonavir
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Nirmatrelvir and Ritonavir in Paxlovid Tablets on Primesep 100 Column

May 5, 2022

Separation type: Liquid Chromatography Mixed-mode

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir and Ritonavir

Condition
Column Promesep 100, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 50-70%
Buffer H2SO4 – 0.5%
Flow Rate 0.5 ml/min
Detection UV 210nm

Description
Class of Compounds Drug
Analyzing Compounds Nirmatrelvir,  Ritonavir

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Nirmatrelvir
Ritonavir
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.