Vitamin E Acetate

Vitamin E Acetate structural formula

CAS Number58-95-7
Molecular FormulaC31H52O3
Molecular Weight472.754
InChI KeyZAKOWWREFLAJOT-CEFNRUSXSA-N
LogP10.3
Synonyms
  • D-alpha-Tocopheryl acetate
  • (2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-
  • 58-95-7
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-
  • (+)-α-Tocopherol acetate
  • (+)-α-Tocopheryl acetate
  • (2R,4'R,8'R)-α-Tocopherol acetate
  • (2R,4'R,8'R)-α-Tocopheryl acetate
  • (R,R,R)-α-Tocopheryl acetate
  • 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, 6-acetate, (2R)-
  • 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
  • Acetate d'α-tocopheryle
  • acetato de α-tocoferilo
  • Combinal E
  • Copherol 12250
  • Copherol 1250
  • Covitol
  • Covitol 1100
  • Covitol 1360
  • Covitol 700
  • Covitol 700WD
  • d-Vitamin E acetate
  • D-α-Tocopherol acetate
  • D-α-TOCOPHERYL ACETATE
  • E 230 Clear
  • E-Toplex
  • E-Vicotrat
  • Evipherol
  • Lutavit E 50
  • Nanotopes
  • Natur-E granulate
  • Spondyvit
  • Tinoderm E
  • TOCOPHEROL ACETATE, (+)-α-
  • TOCOPHERYL ACETATE
  • TOCOPHERYL ACETATE, D-α-
  • TOCOPHERYL D-α ACETATE
  • Tokoferol acetate
  • Vitamin E 230 Clear
  • Vitamin Eα acetate
  • α-Tocopherylacetat
  • Alfacol
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-
  • Contopheron
  • 6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
  • 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*)))-
  • Ecofrol
  • EINECS 200-405-4
  • Ephynal acetate
  • Epsilan-M
  • E-Ferol
  • 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-
  • Tocopherex
  • (+)-alpha-Tocopherol acetate
  • d-alpha-Tocopherol acetate
  • alpha-Tocopherol acetate, (2R,4'R,8'R)-
  • (+)-alpha-Tocopheryl acetate
  • (R,R,R)-alpha-Tocopheryl acetate
  • (2R,4'R,8'R)-alpha-Tocopheryl acetate
  • Tocophrin
  • Tofaxin
  • Endo E Dompe
  • Vitamin Ealpha acetate
  • Vitamin E acetate, d-
  • UNII-A7E6112E4N
  • Simmyungsaengmosu
  • 12741-00-3
  • 1406-70-8
  • 26243-95-8

Applications:

HPLC Analysis of Ascorbic Acid, Retinol (Vitamin A) and Vitamin E acetate in ACE Serum Active Ingredients

October 14, 2010


Mixed-mode HPLC columns allow for separation of compounds with drastically different properties. In this application, highly hydrophilic ascorbic acid is retained and separated from highly hydrophobic retinol (Vitamin A) and Vitamin E Acetate. Ascorbic acid is retained by anion-exchange mechanism and hydrophobic compounds are retained by reversed-phase mechanism. Compounds are monitored by UV detection. Mobile phase is compatible with LC/MS and method can be used to monitor basic and acidic compounds in bio-fluids (serum, blood, urine, saliva, etc.)
Retinol (Vitamin A)  and Vitamin E Acetate

Condition
Column Primesep  SB , 3.0×50 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer Acetic Acid
Flow Rate 0.5 ml/min
Detection UV 270, 325

 

Description
Class of Compounds
 Acid, Vitamin B₆, Hydrophobic, Ionizable
Analyzing Compounds Ascorbic acid (Vitamin C), Retinol (Vitamin A) and Vitamin E Acetate

Application Column

Primesep SB

Column Diameter: 3.2 mm
Column Length: 50 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Ascorbic Acid
Retinol (Vitamin A)
Vitamin E Acetate
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Vitamin E and Vitamin E Acetate on Primesep B Column

March 27, 2004

Primesep B separates Vitamin E and Vitamin E acetate with reversed peak order of a traditional C8 column. The different selectivity is due to an embedded basic functional group on the stationary phase which contributes polar interactions to the separation. Excellent peak shape results with a mass spec compatible mobile phase of water and acetonitrile (MeCN, ACN) with UV detection at 205 nm.

Condition
Column Primesep B, 3.2×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 90/10%
Buffer
Flow Rate 0.5 ml/min
Detection UV 205

Description
Class of Compounds Vitamins, Hydrophilic, Ionizable
Analyzing Compounds Vitamin E,  Vitamin E Acetate

Application Column

Primesep B

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Vitamin E
Vitamin E Acetate
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.