Succinylcholine

CAS Number306-40-1
Molecular FormulaC14H30N2O4
Molecular Weight290.403
InChI KeyAXOIZCJOOAYSMI-UHFFFAOYSA-N
LogP-2.64
Synonyms
  • Succinylcholine
  • 2,2'-[(1,4-Dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethan-1-aminium)
  • Ethanaminium, 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-
  • 306-40-1
  • Suxemethonium
  • 4-04-00-01451
  • Ethanaminium, 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-
  • BRN 1805311
  • Choline, succinyl-
  • Diacetylcholine
  • Dicholine succinate
  • Ditilin
  • Ditiline
  • Succinic acid, diester with choline
  • Succinyl choline
  • UNII-J2R869A8YF
  • Succinocholine
  • Succinoylcholine
  • Succinylbischoline
  • Succinyldicholine
  • Suxamethonium

Applications:

HPLC Determination of Succinylcholine on Newcrom AH Column

June 29, 2021

Separation type: Liquid Chromatography Mixed-mode




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High Performance Liquid Chromatography (HPLC) Method for Analysis of Succinylcholine




Succinylcholine chloride is a short-acting depolarizing neuromuscular blocker used as a short-term muscle relaxant. Succinylcholine is often used as an adjunct therapy in patients undergoing electroconvulsive shock therapy to control muscle contractions that are induced as a result of the electrical impulses delivered during the procedure. By using a Newcrom AH mixed-mode column with a cation-exchange mechanism, Succinylcholine can be determinate in a short time using an isocratic method with a simple mobile phase of water, acetonitrile (MeCN, ACN) and a perchloric acid (HClO4) buffer. UV detection at 200 nm.




 

Condition
Column Newcrom AH, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 15/85%
Buffer  HClO4 – 0.85%
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description
Class of Compounds
 Drug
Analyzing Compounds Succinylcholine

 

Application Column

Newcrom AH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Succinylcholine
Succinylcholine chloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Succinylcholine and Choline Using a Primesep 200 Column

July 11, 2012

 

Condition
Column Primesep 200, 4.6×50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN 0 – 20 %, 7 min
Buffer TFA – 0.05-0.20%
Flow Rate 1.0 ml/min
Detection ELSD 45C

 

Description
Class of Compounds
 Drug, Acid, Paralytic, Hydrophilic, Ionizable
Analyzing Compounds Succinic Acid, Succinylcholine, Choline

 

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Choline
Succinic Acid
Succinylcholine
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.