Succinylcholine chloride

Succinylcholine chloride structural formula

CAS Number71-27-2
Molecular FormulaC14H30Cl2N2O4
Molecular Weight361.300
InChI KeyYOEWQQVKRJEPAE-UHFFFAOYSA-L
LogP-3.47
Synonyms
  • Succinylcholine chloride
  • 2,2'-[(1,4-Dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethan-1-aminium) dichloride
  • Ethanaminium, 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-, chloride (1:2)
  • 71-27-2
  • Ethanaminium, 2,?2'-?[(1,?4-?dioxo-?1,?4-?butanediyl)?bis(oxy)?]?bis[N,?N,?N-?trimethyl-?, chloride (1:2)
  • Choline, chloride, succinate (2:1)
  • Ethanaminium, 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-, dichloride
  • Quelicin chloride
  • Anectine
  • Choline, chloride succinate
  • Choline succinate dichloride
  • Choline, succinyl-, dichloride
  • Diacetylcholine dichloride
  • EINECS 200-747-4
  • (2-Hydroxyethyl)trimethylammonium chloride succinate
  • Lysthenon
  • Lysthenone
  • Midarine
  • Myoplegine
  • NSC 49132
  • Pantolax
  • Quelicin
  • Scoline chloride
  • Succamethonium chloratum
  • Succicuran
  • Succinic acid, bis(beta-dimethylaminoethyl) ester, dimethochloride
  • Succinic acid, diester with choline chloride
  • Succinoylcholine chloride
  • Succinyl bischoline chloride
  • Succinylbischoline dichloride
  • Succinylcholine dichloride
  • Succinylforte
  • Suxamethionium chloride
  • Suxcert
  • Suxinyl
  • Anectine chloride
  • Scoline
  • Sucostrin chloride
  • Succinyldicholine chloride
  • Sukolin
  • Succinyl-asta
  • 3,8-Dioxa-4,7-dioxodercan-1,10-bis(trimethylammonium)dichlorid
  • Succinyl-bis(N-(2-oxyethyl)trimethylammonium)-dichlorid
  • Suxamethonii chloridum
  • Quelicin Preservative Free
  • Sucostrin
  • Cloruro de suxametonio
  • Cloruro di succinilcolina
  • Succinilcolina cloruro
  • Sukcinylcholinchlorid
  • UNII-I9L0DDD30I
  • 2-dimethylaminoethyl succinate dimethochloride
  • Chlorsuccinylcholin
  • anhydrous succinylcholine chloride
  • anhydrous succinylcholine dichloride
  • anhydrous succinyldicholine dichloride
  • anhydrous suxamethonium chloride
  • bis(2-dimethylaminoethyl)succinate bis(methochloride)
  • bis(succinyldichlorocholine)
  • chlorure de succinilcoline
  • succinylcholine dichloride
  • succinylcholine dichloride (anhydrous)
  • succinyldicholine dichloride
  • succinyldicholine dichloride (anhydrous)
  • suxamethonium chloride (anhydrous)
  • suxamethonium dichloride
  • succinylcholine chloride (anhydrous)
  • 10168-63-5

Applications:

HPLC Determination of Succinylcholine on Newcrom AH Column

June 29, 2021

Separation type: Liquid Chromatography Mixed-mode




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High Performance Liquid Chromatography (HPLC) Method for Analysis of Succinylcholine




Succinylcholine chloride is a short-acting depolarizing neuromuscular blocker used as a short-term muscle relaxant. Succinylcholine is often used as an adjunct therapy in patients undergoing electroconvulsive shock therapy to control muscle contractions that are induced as a result of the electrical impulses delivered during the procedure. By using a Newcrom AH mixed-mode column with a cation-exchange mechanism, Succinylcholine can be determinate in a short time using an isocratic method with a simple mobile phase of water, acetonitrile (MeCN, ACN) and a perchloric acid (HClO4) buffer. UV detection at 200 nm.




 

Condition
Column Newcrom AH, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 15/85%
Buffer  HClO4 – 0.85%
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description
Class of Compounds
 Drug
Analyzing Compounds Succinylcholine

 

Application Column

Newcrom AH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Succinylcholine
Succinylcholine chloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Succinylcholine chloride on Newcrom R1 HPLC column

February 16, 2018
Separation of Succinylcholine chloride on Newcrom C18 HPLC column

Succinylcholine chloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Succinylcholine chloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.