Ritodrine

Ritodrine structural formula

CAS Number26652-09-5
Molecular FormulaC17H21NO3
Molecular Weight287.360
InChI KeyIOVGROKTTNBUGK-SJCJKPOMSA-N
LogP1.63
Synonyms
  • Ritodrine
  • 4-[(1R,2S)-1-Hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
  • Benzenemethanol, 4-hydroxy-alpha-[(1S)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (alphaR)-
  • 26652-09-5
  • Benzenemethanol, 4-hydroxy-?-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (?S)-rel-
  • (.+-.)-Ritodrine
  • (R*,S*)-4-Hydroxy-?-[1-[2-(4-hydroxyphenylethyl)amino]ethyl]benzenemethanol
  • Benzenemethanol, 4-hydroxy-?-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (R*,S*)-
  • Benzyl alcohol, p-hydroxy-?-[1-[(p-hydroxyphenethyl)amino]ethyl]-, erythro-
  • Ritodrin
  • ritodrina
  • Benzyl alcohol, p-hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)-, erythro-
  • BRN 2388728
  • EINECS 247-879-9
  • erythro-p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol
  • 4-Hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)benzenemethanol (R*,S*)-
  • Ritodrinium
  • p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol
  • 2-(4-Hydroxyphenethylamino)-1-(4-hydroxyphenyl)propanol
  • UNII-I0Q6O6740J

Applications:

HPLC Determination of Ritodrine on Primesep 100

August 7, 2019

HPLC Method for Ritodrine on Primesep 100 by SIELC Technologies

HPLC Determination of Ritodrine_1181

High Performance Liquid Chromatography (HPLC) Method for Analysis of Ritodrine

Ritodrine (also Yutopar), is a drug used in relaxation of smooth muscle and to stop premature labor. It has been pulled from the US market due to its side effects. Ritodrine can be retained on a Primesep 100 column with great peak shape using isocratic method of 30/70 Acetonitrile (ACN) and water with 0.3% sulfuric acid as buffer. UV Detection 276nm.

 

Condition
Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer H2SO4 – 0.3 %
Flow Rate 1.0 ml/min
Detection UV, 276 nm

 

Description
Class of Compounds
 Drug, Basic, Hydrophobic, Ionizable, Amine
Analyzing Compounds Ritodrine

 

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Ritodrine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Ritodrine on Newcrom R1 HPLC column

May 16, 2018
Separation of Ritodrine on Newcrom R1 HPLC column

Ritodrine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Ritodrine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.