HPLC Determination of Ritodrine on Primesep 100

HPLC Determination of Ritodrine_1181

Ritodrine (also Yutopar), is a drug used in relaxation of smooth muscle and to stop premature labor. It has been pulled from the US market due to its side effects. Ritodrine can be retained on a Primesep 100 column with great peak shape using isocratic method of 30/70 Acetonitrile (ACN) and water with 0.3% sulfuric acid as buffer. UV Detection 276nm.

 

Condition

Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer H2SO4 – 0.3 %
Flow Rate 1.0 ml/min
Detection UV, 276 nm

 

Description

Class of Compounds
Drug, Basic, Hydrophobic, Ionizable, Amine
Analyzing Compounds Ritodrine

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Ritodrine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.