| CAS Number | 26652-09-5 |
|---|---|
| Molecular Formula | C17H21NO3 |
| Molecular Weight | 287.360 |
| InChI Key | IOVGROKTTNBUGK-SJCJKPOMSA-N |
| LogP | 1.63 |
| Synonyms |
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Applications:
HPLC Determination of Ritodrine on Primesep 100
August 7, 2019
Ritodrine (also Yutopar), is a drug used in relaxation of smooth muscle and to stop premature labor. It has been pulled from the US market due to its side effects. Ritodrine can be retained on a Primesep 100 column with great peak shape using isocratic method of 30/70 Acetonitrile (ACN) and water with 0.3% sulfuric acid as buffer. UV Detection 276nm.
Condition
Column Primesep 100, 4.6×150 mm, 5 µm, 100A Mobile Phase MeCN/H2O – 30/70% Buffer H2SO4 – 0.3 % Flow Rate 1.0 ml/min Detection UV, 276 nm
Description
Class of Compounds
Drug, Basic, Hydrophobic, Ionizable, Amine Analyzing Compounds Ritodrine
Application Column
Primesep 100
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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Separation of Ritodrine on Newcrom R1 HPLC column
May 16, 2018
Ritodrine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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