| CAS Number | 94-36-0 |
|---|---|
| Molecular Formula | C14H10O4 |
| Molecular Weight | 242.230 |
| InChI Key | OMPJBNCRMGITSC-UHFFFAOYSA-N |
| LogP | 3.46 |
| Synonyms |
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Applications:
HPLC Determination of Benzoyl Peroxide on Newcrom R1 Column
July 19, 2021
HPLC Method for Benzoyl peroxide, Hydrogen Peroxide on Newcrom R1 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzoyl peroxide.
Hydrogen Peroxide is a chemical compound with the chemical formula H2O2. While most assume it to be a colorless liquid, in it’s natural state, it is pale blue. It’s primary uses are found in bleaching, as a disinfectant, and sewage treatment. On occasion, it is used as acne treatment as well. It is used in a variety of production of organic peroxy compounds and inorganic peroxides.
Benzoic Acid is an organic compound with the chemical formula C7H6O2. It is considered to be the simplest aromatic carboxylic acid. In nature, it can be found in many plants, especially berries. It is used for food preservation of food, as it can inhibit growth of bacteria and mold. While it is safe in food, it can cause irritation to skin, eye, and respiratory systems. You can find detailed UV spectra of Benzoic Acid and information about its various lambda maxima by visiting the following link.
Benzoyl Peroxide is an organic peroxide with the chemical formula C14H10O4. It is a commonly used as topical treatment for mild acne because of its antibacterial, anti keratolytic, and comedolytic properties. It is converted to benzoic acid in the skin and primarily targets the pilosebaceous units.
Benzoyl Peroxide can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN) and water. The analysis method can be UV detected at 235 nm.
| Column | Newcrom R1, 4.6 x 150 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN – 80% |
| Buffer | No |
| Flow Rate | 1.0 ml/min |
| Detection | UV 235 nm |
| Class of Compounds | Hydrophobic |
| Analyzing Compounds | Benzoyl peroxide, Hydrogen Peroxide |
Application Column
Newcrom R1
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Hydrogen Peroxide
Separation of Benzoyl peroxide on Newcrom R1 HPLC column
February 16, 2018
Benzoyl peroxide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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