Finasteride

Molecular Formula	C23H36N2O2
Molecular Weight	372.5
InChI Key	DBEPLOCGEIEOCV-WSBQPABSSA-N
LogP	2
Synonyms	finasteride 98319-26-7 Proscar Propecia Finastid Prostide Chibro-Proscar MK-906 Finpecia Finasterida Finasteridum MK 906 N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide CHEMBL710 NSC-741485

Applications:

HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 Column

February 3, 2023

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HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

Finasteride, also known as Proscar or Propecia, is a popular oral medication used to prevent hair loss and treat enlarged prostates (also known as benign prostatic hyperplasia, BPH). Minoxidil is another drug used to treat male pattern hair loss, as well as high blood pressure, and can be taken both orally or topically. Potassium Sorbate is a popular preservative used in a wide variety of foods, wines, and personal-care products. These 3 compounds can be retained, separated, and analyzed on a mixed-mode Newcrom BH column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid (H2SO4). This analytical method can be UV detected at 225 nm with high resolution and peak symmetry. The retention times and elution order of these compounds can be modified by altering the relative concentrations of MeCN and H2SO4.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Finasteride, Minoxidil and Potassium sorbate

Condition

Column	Primesep 100, 4.6 x 150 mm, 5 µm, 100 A
Mobile Phase	MeCN/H2O – 50/50%
Buffer	H2SO4
Flow Rate	1.0 ml/min
Detection	UV 225 nm
Peak Retention Time

Description

Class of Compounds	Drug
Analyzing Compounds	Finasteride, Minoxidil, Potassium sorbate

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Finasteride
Minoxidil
Potassium sorbate

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.