| CAS Number | 38304-91-5 |
|---|---|
| Molecular Formula | C9H15N5O |
| Molecular Weight | 209.254 |
| InChI Key | ZFMITUMMTDLWHR-UHFFFAOYSA-N |
| LogP | 1.24 |
| Synonyms |
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Applications:
Uv-Vis Spectrum of Minoxidil
February 17, 2026
Access the UV-Vis Spectrum SIELC Library
If you are looking for optimized HPLC method to analyze Minoxidil check our HPLC Applications library
For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.
HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 Column
February 3, 2023
HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 by SIELC Technologies
Finasteride, also known as Proscar or Propecia, is a popular oral medication with the chemical formula C23H36N2O2. It is primarily used to prevent hair loss and treat enlarged prostates (also known as benign prostatic hyperplasia, BPH). On occasion, it is used to treat excessive hair growth. It works as a 5a-reductase inhibitor, which leads to reduced formation of dihydrotestosterone (DHT) from testosterone. You can find detailed UV spectra of Finasteride and information about its various lambda maxima by visiting the following link.
Minoxidil is a drug with the chemical formula C9H15N5O. It is used to treat male pattern hair loss, as well as high blood pressure, and can be taken both orally or topically. It is an adenosine 5′-triphosphate (ATP)-sensitive potassium channel opener, which leads to hyperpolarization of cell membranes.. That allows for more oxygen, blood, and nutrients to follicles. You can find detailed UV spectra of Minoxidil and information about its various lambda maxima by visiting the following link.
Potassium Sorbate is a popular preservative with the chemical formula C6H7KO2. It is used in a wide variety of foods, wines, and personal-care products. It works through inhibiting molds, yeasts, and various other microbes. You can find detailed UV spectra of Potassium Sorbate and information about its various lambda maxima by visiting the following link.
Minoxidil, Potassium sorbate, Finasteride can be retained, separated, and analyzed on a mixed-mode Primesep 100 column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid (H2SO4). This analytical method can be UV detected at 225 nm with high resolution and peak symmetry. The retention times and elution order of these compounds can be modified by altering the relative concentrations of MeCN and H2SO4.
Condition
| Column | Primesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O – 50/50% |
| Buffer | H2SO4 |
| Flow Rate | 1.0 ml/min |
| Detection | UV 225 nm |
Description
| Class of Compounds | Drug |
| Analyzing Compounds | Minoxidil, Potassium sorbate, Finasteride |
Application Column
Primesep 100
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Minoxidil
Potassium sorbate
Separation of Minoxidil on Newcrom R1 HPLC column
May 16, 2018
Minoxidil can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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