Minoxidil

Minoxidil structural formula

CAS Number38304-91-5
Molecular FormulaC9H15N5O
Molecular Weight209.254
InChI KeyZFMITUMMTDLWHR-UHFFFAOYSA-N
LogP1.24
Synonyms
  • Minoxidil
  • 3-Oxo-6-(piperidin-1-yl)-3lambda5-pyrimidine-2,4-diamine
  • 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
  • 38304-91-5
  • 5-25-12-00317
  • 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
  • 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide
  • 2,4-Diamino-6-piperidinopyrimidine 3-oxide
  • 2,4-Pyrimidinediamine, 2,3-dihydro-6-(1-piperidinyl)-, 3-oxide
  • 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
  • 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperodinopyrimidine
  • Alopexil
  • Alostil
  • Loniten
  • Lonolox
  • Minoximen
  • Normoxidil
  • Pierminox
  • Prexidil
  • Rogaine
  • Tricoxidil
  • BRN 0886240
  • 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
  • EINECS 253-874-2
  • 6-Piperidino-2,4-diaminopyrimidine 3-oxide
  • 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
  • Regaine
  • 2,6-Diamino-4-piperidinopyrimidin-1-oxid
  • Theroxidil
  • Men's Rogaine
  • Minodyl
  • 2,4-Diamino-6-piperidinilpirimidina-3-ossido
  • Minossidile
  • Minoxidilum
  • UNII-5965120SH1

Applications:

HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 Column

February 3, 2023

HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 by SIELC Technologies
Method for Separation of Finasteride, Minoxidil and Potassium sorbate on Primesep 100 by SIELC Technologies

Finasteride, also known as Proscar or Propecia, is a popular oral medication used to prevent hair loss and treat enlarged prostates (also known as benign prostatic hyperplasia, BPH). Minoxidil is another drug used to treat male pattern hair loss, as well as high blood pressure, and can be taken both orally or topically. Potassium Sorbate is a popular preservative used in a wide variety of foods, wines, and personal-care products. These 3 compounds can be retained, separated, and analyzed on a mixed-mode Newcrom BH column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid (H2SO4). This analytical method can be UV detected at 225 nm with high resolution and peak symmetry. The retention times and elution order of these compounds can be modified by altering the relative concentrations of MeCN and H2SO4.

High Performance Liquid Chromatography (HPLC) Method for Analysis of  Finasteride, Minoxidil and Potassium sorbate

Condition

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 50/50%
BufferH2SO4
Flow Rate1.0 ml/min
DetectionUV 225 nm
Peak Retention Time

Description

Class of CompoundsDrug
Analyzing CompoundsFinasteride, Minoxidil, Potassium sorbate

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Finasteride
Minoxidil
Potassium sorbate
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Minoxidil on Newcrom R1 HPLC column

May 16, 2018
Separation of Minoxidil on Newcrom R1 HPLC column

Minoxidil can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Minoxidil
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.