Vigabatrin

Molecular Formula	C6H11NO2
Molecular Weight	128.16
InChI Key	PJDFLNIOAUIZSL-UHFFFAOYSA-N
LogP	-3.2
Synonyms	vigabatrin 4-aminohex-5-enoic acid Sabril 60643-86-9 68506-86-5 Vigabatrine gamma-Vinyl GABA 4-Amino-5-hexenoic acid gamma-Vinyl-GABA 5-Hexenoic acid, 4-amino- Vigabatrinum 4-Aminohexenoic acid gamma-Vinyl-gamma-Aminobutyric Acid MDL-71754 GVG RMI-71754 CPP-109 CPP109 (+/-)-Vigabatrin (R,S)-4-Amino-5-hexenoic acid MDL 71,754 4-Amino-hex-5-enoic acid (+/-)-gamma-Vinyl-GABA CHEMBL89598 CHEBI:63638 Vigabatrine [French] Vigabatrinum [Latin] Vigabatrina [Spanish] VINYL GAMMA-AMINOBUTYRIC ACID MFCD00274577 NCGC00016087-06 Vigabatrina Sabrilex 4-aminohex-5-enoic acid/S(+)-Gamma-VIGABATRIN gamma Vinyl GABA Sabril (TN) (4R)-4-aminohex-5-enoic acid (4S)-4-aminohex-5-enoic acid Vigabatrin [USAN:INN:BAN] MDL 71754 RMI 71754 Hexenoic acid, 4-amino SR-01000075653 (S)-4-Amino-5-hexenoic Acid (+-)-gamma-Vinyl GABA Kigabeq MFCD00274076 (1)-4-Aminohex-5-enoic acid CPP 109 Vigabatrin solution Prestwick_837 EINECS 270-929-6 CAS-60643-86-9 RMI-71890 S(+)--Vigabatrin .gamma.-vinyl GABA .gamma.-Vinyl-GABA Spectrum_000368 SpecPlus_000664 (y)-gamma-Vinyl GABA Prestwick0_000501 Prestwick1_000501 Prestwick2_000501 Prestwick3_000501 Spectrum3_001825 (?)-gamma-Vinyl GABA Biomol-NT_000247 V 8261 DSSTox_CID_21153 DSSTox_RID_79637 DSSTox_GSID_41153 Lopac0_001277 M071754 SCHEMBL26714 (+/-)-gamma-Vinyl GABA BSPBio_000421 BSPBio_003469 KBioSS_000848 Vigabatrin (JAN/USP/INN) (A+/-)-gamma-Vinyl GABA DivK1c_006760 SPECTRUM1502036 (+/-)-?-Vinyl GABA SPBio_002342 (+/-)-4-Aminohexenoic acid BPBio1_000465 BPBio1_000925 GTPL4821 R(-)-GAMMA-VINYL GABA DTXSID4041153 Vinyl .gamma.-aminobutyric Acid HSDB 8395 KBio1_001704 KBio2_000848 KBio2_003416 KBio2_005984 KBio3_002973 AMY6474 AOB6800 S(+)-4-AMINOHEXENOICACID HMS1569F03 HMS2094M21 HMS2096F03 HMS3263P16 (plusmn)-4-aminohex-5-enoic acid BCP16220 Tox21_110301 Tox21_501277 BDBM50118886 AKOS015854596 ACN-036276 CCG-205350 CS-0791 DB01080 LP01277 SDCCGSBI-0051243.P004 (?)-4-AMINOHEX-5-ENOIC ACID .gamma.-Vinyl-.gamma.-aminobutyric acid NCGC00016087-03 NCGC00016087-04 NCGC00016087-05 NCGC00016087-07 NCGC00016087-08 NCGC00016087-09 NCGC00016087-11 NCGC00016087-22 NCGC00024802-02 NCGC00024802-03 NCGC00024802-04 NCGC00024802-05 NCGC00024802-06 NCGC00261962-01 AS-11778 HY-15399 SY263247 SBI-0051243.P003 ( inverted question mark)-gamma-Vinyl GABA AB0010729 DB-117820 AB00053309 EU-0101277 FT-0675811 FT-0675812 FT-0700968 C07500 D00535 W-5102 AB00053309_04 Q421663 Q-201924 SR-01000075653-1 SR-01000075653-4 SR-01000075653-6 ( inverted exclamation markA)-4-aminohex-5-enoic acid BRD-A07893380-001-01-6 Z2235791448 Vigabatrin, European Pharmacopoeia (EP) Reference Standard Vigabatrin, United States Pharmacopeia (USP) Reference Standard Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

Applications:

HPLC Method for Determination of Gamma-aminobutyric acid (GABA), Vigabatrin, Phenibut, Pregabalin, Baclofen on Primesep 100 Column

June 15, 2021

View Application

Separation type: Liquid Chromatography Mixed-mode

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High Performance Liquid Chromatography (HPLC) Method for Analysis of Gamma-aminobutyric acid (GABA), Vigabatrin, Phenibut, Pregabalin, Baclofen

All gabapentinoids can be retained and separated on the Primesep 100 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and Ammonium Formate (AmFm) buffer. Detection can be achieved with mass spectrometry (MS), evaporative light scattering detection (ELSD) and Charged aerosol detection (CAD).

Column	Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase	MeCN/H2O – 30/70%
Buffer	AmFm pH 3.0 – 50 mM
Flow Rate	1.0 ml/min
Detection	CAD (Corona) (MS-compatible mobile phase)

Class of Compounds	Acid, Drug
Analyzing Compounds	Gamma-aminobutyric acid (GABA), Vigabatrin, Phenibut, Pregabalin, Baclofen

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Baclofen
Phenibut
Pregabalin
Vigabatrin
gamma-Aminobutyric Acid (GABA)

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.