Phenibut

CAS Number	1078-21-3
Molecular Formula	C10H13NO2
Molecular Weight	179.22
InChI Key	DAFOCGYVTAOKAJ-UHFFFAOYSA-N
LogP	-1.6
Synonyms	Phenibut 4-Amino-3-phenylbutanoic acid 1078-21-3 4-Amino-3-phenylbutyric acid Fenibut Phenylgamma Fenigama Phenigam Phenylgam Fenigam Pgaba PhGaba beta-Phenyl-gamma-aminobutyric acid beta-(Aminomethyl)hydrocinnamic acid beta-Phenyl-gamma-aminobutyrate 4-Amino-3-phenyl-butyric acid beta-(Aminomethyl)benzenepropanoic acid Benzenepropanoic acid, .beta.-(aminomethyl)- Benzenepropanoic acid, beta-(aminomethyl)- 4-Amino-3-pheny-butyric acid phenyl-GABA Benzenepropanoic acid, b-(aminomethyl)- Phenigama EINECS 214-079-6 BRN 2804903 Phenibut; Fenibut Benzenepropanoic acid, beta-(aminomethyl)-, hydrochloride BUTYRIC ACID, 4-AMINO-3-PHENYL- Oprea1_183000 Oprea1_381119 4-14-00-01723 (Beilstein Handbook Reference) ARONIS24466 SCHEMBL340838 3-phenyl-4-aminobutanoic acid CHEMBL315818 DTXSID70870838

Applications:

HPLC Method for Determination of Gamma-aminobutyric acid (GABA), Vigabatrin, Phenibut, Pregabalin, Baclofen on Primesep 100 Column

June 15, 2021

View Application

Separation type: Liquid Chromatography Mixed-mode

View on hplc.cloud

High Performance Liquid Chromatography (HPLC) Method for Analysis of Gamma-aminobutyric acid (GABA), Vigabatrin, Phenibut, Pregabalin, Baclofen

All gabapentinoids can be retained and separated on the Primesep 100 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and Ammonium Formate (AmFm) buffer. Detection can be achieved with mass spectrometry (MS), evaporative light scattering detection (ELSD) and Charged aerosol detection (CAD).

Column	Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase	MeCN/H2O – 30/70%
Buffer	AmFm pH 3.0 – 50 mM
Flow Rate	1.0 ml/min
Detection	CAD (Corona) (MS-compatible mobile phase)

Class of Compounds	Acid, Drug
Analyzing Compounds	Gamma-aminobutyric acid (GABA), Vigabatrin, Phenibut, Pregabalin, Baclofen

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Baclofen
Phenibut
Pregabalin
Vigabatrin
gamma-Aminobutyric Acid (GABA)

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.