Thiomuscimol

Thiomuscimol

CAS Number62020-54-6
Molecular FormulaC4H6N2OS
Molecular Weight130.17
InChI KeyQVBUOPGWPXUAHT-UHFFFAOYSA-N
LogP-1.3
Synonyms
  • Thiomuscimol
  • 62020-54-6
  • 5-(aminomethyl)-1,2-thiazol-3-one
  • 5-(Aminomethyl)isothiazol-3(2H)-one
  • 5-Aminomethyl-3-isothiazolol
  • 5-(aminomethyl)-2,3-dihydro-1,2-thiazol-3-one
  • 5-(Aminomethyl)-3(2H)-isothiazolone
  • 3(2H)-Isothiazolone,5-(aminomethyl)-
  • CHEMBL133628
  • SCHEMBL7778711
  • BDBM85196
  • DTXSID00211078
  • CAS_5448
  • NSC_5448
  • ZINC84548952
  • AKOS006338836
  • 5-(Aminomethyl)- 3(2H)-isothiazolone
  • 5-(AMINOMETHYL)-1,2-THIAZOL-3-OL
  • FT-0675183
  • EN300-7298563
  • Q15634088

Applications:

HPLC Method for Separation of Muscimol and Thiomuscimol Primesep 100 Column

February 27, 2023

HPLC Method for Separation of Muscimol and Thiomuscimol on Primesep 100 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Muscimol and Thiomuscimol Primesep 100 Column by SIELC Technologies
Method for Separation of Muscimol and Thiomuscimol on Primesep 100 by SIELC Technologies

Muscimol (also known as agarin or pantherine) is a psychoactive GABA-A agonist. It is a naturally occurring compound found in Amanita muscaria and related species of mushrooms. Thiomuschimol is also a GABA-A agonist with a near identical structure as Muscimol with the Oxygen in the ring replaced with a Sulfur. These structurally similar psychoactive drugs can be retained, separated, and analyzed on a mixed-mode Primesep 100 column with a mobile phase consisting of water, Acetonitrile (MeCN), and Ammonium formate (AmFm). This analytical method can be UV detected at 250 nm with high resolution and peak symmetry.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Muscimol and Thiomuscimol

Condition

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 20/80%
BufferAmmonium Formate pH 4.0- 40 mM
Flow Rate1.0 ml/min
DetectionUV 250 nm
Peak Retention Time5.22 min, 6.52 min

Description

Class of CompoundsIsoxazole, Heterocyclic
Analyzing CompoundsMuscimol, Thiomuscimol

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Muscimol
Thiomuscimol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.