S-(Carboxymethyl)-L-cysteine

S-(Carboxymethyl)-L-cysteine structural formula

CAS Number638-23-3
Molecular FormulaC5H9NO4S
Molecular Weight179.191
InChI KeyGBFLZEXEOZUWRN-VKHMYHEASA-N
LogP-1.65
Synonyms
  • S-(Carboxymethyl)-L-cysteine
  • L-Cysteine, S-(carboxymethyl)-
  • 638-23-3
  • S-Carbocysteine
  • (R)-S-(Carboxymethyl)cysteine
  • (L)-2-Amino-3-(carboxymethylthio)propionic acid
  • BRN 1725012
  • S-Carboxylmethyl-L-cysteine
  • 3-(Carboxymethylthio)-L-alanine
  • EINECS 211-327-5
  • Muciclar
  • Mucocis
  • Mucodyne
  • NSC 14156
  • Reomucil
  • Rhinathiol
  • Rinatiol
  • Thiodril
  • Transbronchin
  • Bronchokod
  • Lisomucil
  • Superthiol sirup
  • Mucojet sirup
  • Mucolex sirup
  • Siroxyl
  • Carbocisteina
  • Carbocisteinum
  • Mucotron
  • UNII-740J2QX53R
  • L-(Carboxymethyl)cysteine
  • Mucolase
  • Loviscol
  • Chilvax
  • PectDrill
  • Mucotab
  • Mucosol
  • L-3-((carboxymethyl)thio)alanine
  • S-(carboxymethyl)-(R)-cysteine
  • S-carboxymethylcysteine
  • carbocysteine
  • S-carboxymethyl-L-cysteine
  • 11139-64-3

Applications:

HPLC Determination of Carbocisteine on Primesep 100 Column

July 31, 2019

HPLC Method for Carbocisteine, S-(Carboxymethyl)-L-cysteine on Primesep 100 by SIELC Technologies

Carbocisteine

High Performance Liquid Chromatography (HPLC) Method for Analysis of Carbocisteine, S-(Carboxymethyl)-L-cysteine.

Carbocisteine, or carbocysteine, is a drug designed to clear the mucus from the upper and lower airways. It’s primarily available in tablet form. It can be retained on a Primesep 100 Column in about 5 minutes. Primesep 100 is a reverse-phase (RP) mixed-mode column with embedded acidic ion-pairing groups.

Condition
Column Primesep 100
Mobile Phase MeCN/H2O – 10/90%
Buffer H2SO4 – 0.05 %
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description
Class of Compounds
 Acid, Hydrophilic, Ionizable, Carboxylic acid, Drug, Carbocyclic, Amino acid
Analyzing Compounds Carbocisteine, S-(Carboxymethyl)-L-cysteine

 

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Carbocisteine
S-(Carboxymethyl)-L-cysteine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of S-(Carboxymethyl)-L-cysteine on Newcrom R1 HPLC column

May 16, 2018
Separation of S-(Carboxymethyl)-L-cysteine on Newcrom R1 HPLC column

S-(Carboxymethyl)-L-cysteine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
S-(Carboxymethyl)-L-cysteine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.