N,N-Dimethyl-5-methoxytryptamine

CAS Number1019-45-0
Molecular FormulaC13H18N2O
Molecular Weight218.29
InChI KeyZSTKHSQDNIGFLM-UHFFFAOYSA-N
LogP1.5
Synonyms
  • N,N-Dimethyl-5-methoxytryptamine
  • 5-Methoxy-N,N-dimethyltryptamine
  • 1019-45-0
  • Methoxybufotenin
  • O-Methylbufotenine
  • MeODMT
  • 5-MeO-DMT
  • Methylbufotenine
  • 5-Methoxydimethyltryptamine
  • Bufotenine, O-methyl-
  • 3-(2-Dimethylaminoethyl)-5-methoxyindole
  • 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
  • 1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-
  • CT 4334
  • Methoxydimethyltryptamines
  • 5-Methoxy-N,N-dimethyl-1H-indole-3-ethanamine
  • UNII-X0MKX3GWU9
  • NSC 88624
  • INDOLE, 3-(2-(N,N-DIMETHYLAMINO)ETHYL)-5-METHOXY-
  • 5-OMe-DMT

Applications:

HPLC Separation of Biogenic Amines on Primesep 100 Column

2020-04-30
Tryptophan is an essential amino acid used in the synthesis of proteins. Tryptamine is structurally similar to tryptophan. Serotonin is a neurotransmitter derived from tryptophan. Dimethyltryptamine and 5-MeO-DMT are psychedelic substances derived from tryptamine. All the compounds have similar structures and can present difficulties to separation in reverse-phase HPLC. They can be separated using the Primesep 100 mixed-mode column in gradient analysis with acetonitrile (ACN) and water mobile phase with ammonium formate (AmFm) buffer, making the method MS-compatible. The amines can also be UV detected at 280nm.

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 40-50%, 15 min
Buffer Gradient AmFm pH 3.0- 20-80 mM, 15 min
Flow Rate 1.0 ml/min
Detection UV 280 nm,  MS-compatible mobile phase
 

Description

Class of Compounds Drug, Hydrophilic, Supplements, Monoamine,  Neurotransmitter
Analyzing Compounds Serotonin, Tryptophan, N,N-dimethyltryptophan, N,N-Dimethyl-5-methoxytryptamine, Tryptamine, N,N-dimethyltryptamine
 
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.
Application Analytes:
N,N-Dimethyl-5-methoxytryptamine
N,N-Dimethyltryptamine
N,N-dimethyltryptophan
Serotonin
Tryptamine
Tryptophan