| CAS Number | 22204-53-1 |
|---|---|
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.264 |
| InChI Key | CMWTZPSULFXXJA-VIFPVBQESA-N |
| LogP | 3.18 |
| Synonyms |
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Applications:
HPLC Determination of Naproxen on Primesep 100 Column
July 30, 2020
HPLC Method for Naproxen, Naproxen Sodium on Primesep 100 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Naproxen, Naproxen Sodium.
Naproxen is a common NSAID used for pain relief and fever reducer. It has the chemical formula C14H14O3. It works through inhibiting the body’s production of prostaglandins, therefore preventing pain and inflammation. It is available over-the-counter at lower dosages, and through prescription at higher dosages. As a NSAID, it carries a risk of heart attack, stroke, and gastrointestinal bleeding.
You can find detailed UV spectra of Naproxen, Naproxen Sodium and information about its various lambda maxima by visiting the following link.
Naproxen, Naproxen Sodium can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using UV.
| Column | Primesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O – 40/60% |
| Buffer | H2SO4 – 0.1% |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Hydrophobic, Ionizable |
| Analyzing Compounds | Naproxen, Naproxen Sodium |
Application Column
Primesep 100
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Naproxen Sodium
Separation of Naproxen on Newcrom R1 HPLC column
February 16, 2018
Naproxen can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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