Menthol

Menthol structural formula

CAS Number1490-04-6
Molecular FormulaC10H20O
Molecular Weight156.269
InChI KeyNOOLISFMXDJSKH-UHFFFAOYSA-N
LogP3.40
Synonyms
  • Menthol
  • 5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
  • Cyclohexanol, 5-methyl-2-(1-methylethyl)-
  • 1490-04-6
  • Cyclohexanol, 5-methyl-2-(1-methylethyl)-
  • 5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
  • DL-Menthol
  • 1-Methyl-4-isopropyl-3-cyclohexanol
  • 2-Isopropyl-5-methylcyclohexan-1-ol
  • 2-Isopropyl-5-methylcyclohexanol
  • 3-Hydroxy-p-menthane
  • 5-Methyl-2-(1-methylethyl)cyclohexanol
  • 5-Methyl-2-isopropylcyclohexanol
  • CYCLOHEXANOL, 5-METHYL-2-ISOPROPYL-
  • DL-mentol
  • Menthyl alcohol
  • p-Menthan-3-ol
  • Caswell No. 540
  • EINECS 216-074-4
  • EPA Pesticide Chemical Code 051601
  • Mineral ice
  • UNII-L7T10EIP3A
  • Mentholum
  • 1-Methyl-4-isopropyl-3-hydroxycyclohexane
  • 3-p-Menthanol
  • 3-p-Menthol
  • 4-Isopropyl-1-methylcyclohexan-3-ol
  • 5-Methyl-2-(1-methylethyl)-Cyclohexanol
  • 5-Methyl-2-(1-methylethyl)-cyclohexanol
  • menthols

Applications:

HPLC Determination of Menthol on Newcrom R1 Column

October 1, 2020

HPLC Method for Menthol on Newcrom R1 by SIELC Technologies

Menthol is a naturally occurring chemical found in mint plants. It is known for it’s cooling effect and is often used in candy, gum, and medicine. Besides flavor, it also has pain relieving properties It has the the chemical formula C10H20O.

Menthol can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) without a buffer. Detection is performed using RI.

Condition

 
Column Newcrom R1, 3.2 x 100 mm, 3 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 50/50%
Buffer No
Flow Rate 0.5 ml/min
Detection RI

Description
Class of Compounds Alcohol
Analyzing Compounds Menthol

 

Application Column

Newcrom R1

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Menthol
Application Detection:
RI Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Menthol on Newcrom R1 HPLC column

May 16, 2018
Separation of Menthol on Newcrom R1 HPLC column

Menthol can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Menthol
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.