Menthol

Menthol structural formula

CAS Number1490-04-6
Molecular FormulaC10H20O
Molecular Weight156.269
InChI KeyNOOLISFMXDJSKH-UHFFFAOYSA-N
LogP3.40
Synonyms
  • Menthol
  • 5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
  • Cyclohexanol, 5-methyl-2-(1-methylethyl)-
  • 1490-04-6
  • Cyclohexanol, 5-methyl-2-(1-methylethyl)-
  • 5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
  • DL-Menthol
  • 1-Methyl-4-isopropyl-3-cyclohexanol
  • 2-Isopropyl-5-methylcyclohexan-1-ol
  • 2-Isopropyl-5-methylcyclohexanol
  • 3-Hydroxy-p-menthane
  • 5-Methyl-2-(1-methylethyl)cyclohexanol
  • 5-Methyl-2-isopropylcyclohexanol
  • CYCLOHEXANOL, 5-METHYL-2-ISOPROPYL-
  • DL-mentol
  • Menthyl alcohol
  • p-Menthan-3-ol
  • Caswell No. 540
  • EINECS 216-074-4
  • EPA Pesticide Chemical Code 051601
  • Mineral ice
  • UNII-L7T10EIP3A
  • Mentholum
  • 1-Methyl-4-isopropyl-3-hydroxycyclohexane
  • 3-p-Menthanol
  • 3-p-Menthol
  • 4-Isopropyl-1-methylcyclohexan-3-ol
  • 5-Methyl-2-(1-methylethyl)-Cyclohexanol
  • 5-Methyl-2-(1-methylethyl)-cyclohexanol
  • menthols

Applications:

HPLC Determination of Menthol on Newcrom R1 Column

2020-10-01


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Condition

 

Column Newcom R1, 3.2×100 mm, 35 µm, 100A
Mobile Phase MeCN/H2O – 50/50%
Buffer No
Flow Rate 0.5 ml/min
Detection RI

Description

Class of Compounds Alcohol
Analyzing Compounds Menthol

 

Application Analytes:
Menthol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Newcrom R1

The Newcrom columns are a family of reverse phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 columns are standard reverse phase columns with octyldecyl silane chains (C18) attached to porous silica. We have also designed a line of Newcrom R1 columns with a new outer design. This column and corresponding adapter entirely eliminate the need for any high-pressure fittings or tubing as well as minimizing all possible dead volumes. Furthermore, if a leak ever occurs in the high-pressure column inlet, the mobile phase is contained within the column adapter (no external leakage).

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Separation of Menthol on Newcrom R1 HPLC column

2018-05-16
Separation of Menthol on Newcrom R1 HPLC column

Menthol can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Analytes:
Menthol
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.

Newcrom R1

The Newcrom columns are a family of reverse phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 columns are standard reverse phase columns with octyldecyl silane chains (C18) attached to porous silica. We have also designed a line of Newcrom R1 columns with a new outer design. This column and corresponding adapter entirely eliminate the need for any high-pressure fittings or tubing as well as minimizing all possible dead volumes. Furthermore, if a leak ever occurs in the high-pressure column inlet, the mobile phase is contained within the column adapter (no external leakage).

Select options