Lisinopril dihydrate

Lisinopril dihydrate structural formula

CAS Number83915-83-7
Molecular FormulaC21H35N3O7
Molecular Weight441.525
InChI KeyCZRQXSDBMCMPNJ-ZUIPZQNBSA-N
LogP-0.0887
Synonyms
  • Lisinopril dihydrate
  • N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline--water (1/2)
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2)
  • 83915-83-7
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, dihydrate
  • (S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate
  • (S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate
  • UNII-E7199S1YWR
  • Ranolip
  • (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate
  • Lisinopril
  • Renacor

Applications:

HPLC Separation of Enalapril and Lisinopril on Newcrom AH Column

June 3, 2021

HPLC Method for Enalapril, Lisinopril, Lisinopril dihydrate on Newcrom AH by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Enalapril and Lisinopril

Enalapril is an ACE inhibitor medication with the chemical formula C20H28N2O5. It is used to treat hypertension, symptomatic heart failure, and asymptomatic left ventricular dysfunction. It also exhibited the ability to reduce the progression of kidney disease. Generic versions of it began their production in 2000.

Lisinopril is a medications that work on the kidneys to help lower blood pressure. It can be used for heart failure and for people who’ve had a heart attack. Like Enalapril, it is an ACE inhibitor. It has the chemical formula C21H31N3O5.

By using a Newcrom AH mixed-mode column with a cation-exchange mechanism, enalapril and lisinopril, can be baseline separated in a short time using an isocratic method with a simple mobile phase of water, acetonitrile (MeCN, ACN) and a sulfuric acid (H2SO4) buffer. UV detection at 210 nm.

Condition
Column Newcrom AH, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 50/50%
Buffer  H2SO4 – 0.5%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description
Class of Compounds
 Drug
Analyzing Compounds Enalapril, Lisinopril, Lisinopril dihydrate

 

Application Column

Newcrom AH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Enalapril
Lisinopril
Lisinopril dihydrate
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Lisinopril dihydrate on Newcrom R1 HPLC column

February 16, 2018
Separation of Lisinopril dihydrate on Newcrom C18 HPLC column

Lisinopril dihydrate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Lisinopril dihydrate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.