Lisinopril

Lisinopril structural formula

CAS Number76547-98-3
Molecular FormulaC21H31N3O5
Molecular Weight405.495
InChI KeyRLAWWYSOJDYHDC-BZSNNMDCSA-N
LogP-1.22
Synonyms
  • Lisinopril
  • N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-
  • 76547-98-3
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-
  • Acerbon
  • Alapril
  • Inopril
  • Linopril
  • Lisipril
  • Lisopril
  • Lisoril
  • Lispril
  • Listril
  • Lizonoton
  • L-Proline, 1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-, (S)-
  • N-(1(S)-Carboxy-3-phenylpropyl)-L-lysyl-L-proline
  • N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline
  • Nanopril
  • Noperten
  • Presiten
  • Prinivil
  • Prinvil
  • Tensopril
  • Vivatec
  • Zestril
  • BRN 4276619
  • EINECS 278-488-1
  • Lysinopril
  • (S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline
  • N2-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl-L-proline
  • Lisinal
  • Sinopril
  • Sinopryl
  • Acercomp
  • Inhibril
  • Novatec
  • Lisinoprilum
  • UNII-7Q3P4BS2FD
  • Zestoretic
  • L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-L-lysyl)-, (S)-
  • Diroton
  • Lisitec
  • Lizinopril
  • Optimon
  • Skopryl
  • Vitopril
  • (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline
  • lisinopril anhydrous

Applications:

HPLC Separation of Enalapril and Lisinopril on Newcrom AH Column

2021-06-03

Separation type: Liquid Chromatography Mixed-mode

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High Performance Liquid Chromatography (HPLC) Method for Analysis of Enalapril and Lisinopril
Enalapril and lisinopril are medications that work on the kidneys to help lower blood pressure. Lisinopril can be used for heart failure and for people who’ve had a heart attack. Enalapril can also be used for heart failure but not heart attacks. By using a Newcrom AH mixed-mode column with a cation-exchange mechanism, enalapril and lisinopril, can be baseline separated in a short time using an isocratic method with a simple mobile phase of water, acetonitrile (MeCN, ACN) and a sulfuric acid (H2SO4) buffer. UV detection at 210 nm.


Condition

Column Newcrom AH, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 50/50%
Buffer  H2SO4 - 0.5%
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description

Class of Compounds Drug
Analyzing Compounds Enalapril,  Lisinopril, Maleic Acid
 
Application Analytes:
Enalapril
Lisinopril
Lisinopril dihydrate

Separation of Lisinopril on Newcrom R1 HPLC column

2018-02-16
Separation of Lisinopril on Newcrom C18 HPLC column

Lisinopril can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com" or by phone: 847-229-2629.

Application Analytes:
Lisinopril