HPLC Method for Analysis of Fitusiran on OligoMG Column

Separation type: Bridge Ion Separation Technology, or BIST™ by SIELC Technologies

HPLC Method for Analysis Fitusiran on OligoMg Column by SIELC Technologies

HPLC Method for Analyzing Fitusiran on OligoMg Column by SIELC Technologies

Fitusiran is a relatively new therapeutic agent developed for the treatment of hemophilia A and B, including in patients with or without inhibitors.

Using SIELC’s newly introduced BIST™ method, this oligonucleotide can be retained on a OligoMg column. Using this new and unique analysis method, oligonucleotide can be separated, retained, and detected at 260 nm.

Please read more on oligonucleotides analysis by HPLC in our June 2024 newsletter.

Condition

Column	OligoMg, 4.6 x 100 mm, 3 µm, 100 A
Mobile Phase	Gradient MeCN 60-10%, 10 min
Buffer	none
Flow Rate	1.0 ml/min
Detection	UV 260 nm

Description

Class of Compounds	Drug, RNA
Analyzing Compounds	Fitusiran

Application Column

OligoMg

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 3 µm
Pore Size: 100 A

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Fitusiran

UV Detection

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