HPLC Determination of Escitalopram (Cipralex) on Primesep SB Column

HPLC Method for Escitalopram on Primesep SB by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Escitalopram.

Escitalopram is a type of antidepressant known as a selective serotonin reuptake inhibitor with the chemical formula C20H21FN2O. It is used to restore serotonergic function in the treatment of depression and anxiety. It is formulated as an oxalate salt. Escitalopram has a lot of side effects that include headache, nausea, and trouble sleeping.

Escitalopram can be retained on Primesep SB, a reverse-phase (RP) mixed-mode column with embedded strong basic ion-pairing groups, using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. UV detection at 240 nm.

Condition
Column Primesep SB, 3.2 x 50 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 20/80%
Buffer H2SO4 – 0.2%
Flow Rate 1.0 ml/min
Detection 240 nm

Description
Class of Compounds Drug, Hydrophobic
Analyzing Compounds Escitalopram

 

Application Column

Primesep SB

Column Diameter: 3.2 mm
Column Length: 50 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Escitalopram
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.