Escitalopram

 

CAS Number128196-01-0
Molecular FormulaC20H21FN2O
Molecular Weight324.4
InChI KeyWSEQXVZVJXJVFP-FQEVSTJZSA-N
LogP3.2
Synonyms
  • Escitalopram
  • 128196-01-0
  • (S)-Citalopram
  • S(+)-Citalopram
  • (+)-Citalopram
  • Seroplex
  • S-(+)-Citalopram
  • Cipralex
  • Escitalopram [INN]
  • (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
  • UNII-4O4S742ANY
  • Esertia
  • Escitalopram (INN)
  • CHEMBL1508
  • (s)-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
  • 4O4S742ANY
  • R-Citalopram
  • CHEBI:36791
  • (+)-(S)-1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile
  • 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, (1S)-
  • 5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, (1S)-
  • Esertia (TN)
  • Escitalopram [INN:BAN]

Applications:

HPLC Determination of Escitalopram (Cipralex) on Primesep SB Column

March 18, 2021

 

Separation type: Liquid Chromatography Mixed-mode

 

 


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High Performance Liquid Chromatography (HPLC) Method for Analysis of Escitalopram

Escitalopram is a type of antidepressant known as a selective serotonin reuptake inhibitor. It is used to restore serotonergic function in the treatment of depression and anxiety. Escitalopram helps many people recover from depression. It can be retained on Primesep SB, a reverse-phase (RP) mixed-mode column with embedded strong basic ion-pairing groups, using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. UV detection at 240 nm.

Condition
Column Primesep SB, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 20/80%
Buffer H2SO4 – 0.2%
Flow Rate 1.0 ml/min
Detection 240 nm

Description
Class of Compounds Drug, Hydrophobic
Analyzing Compounds Escitalopram

 

Application Column

Primesep SB

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Escitalopram
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.