| CAS Number | 49562-28-9 |
|---|---|
| Molecular Formula | C20H21ClO4 |
| Molecular Weight | 360.830 |
| InChI Key | YMTINGFKWWXKFG-UHFFFAOYSA-N |
| LogP | 4.71 |
| Synonyms |
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Applications:
HPLC Separation of Fenofibric Acid and Fenofibrate on Newcrom AH Column
September 1, 2021
HPLC Method for Fenofibric acid, Fenofibrate on Newcrom AH by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Fenofibric acid, Fenofibrate.
Fenofibric acid is used to treat high levels of cholesterol and triglyceride in blood, which can help prevent pancreatitis. It works through activating peroxisome proliferator-activated receptor alpha. This leads to increased activity lipoprotein lipase and decreased production of proprotein.
Fenofibrate is used to treat high levels of cholesterol and triglyceride in blood, which can help prevent pancreatitis. It works when it is converted into Fenofibric acid, listed above.
Fenofibric acid, Fenofibrate can be retained and analyzed using the Newcrom AH stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a formic acid buffer. Detection is performed using UV.
| Column | Newcrom AH, 3.2 x 100 mm, 3 µm, 100 A, dual ended |
| Mobile Phase | MeCN – 45% |
| Buffer | Formic Acid – 0.05% |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 286 nm |
| Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, Supplements |
| Analyzing Compounds | Fenofibric acid, Fenofibrate |
Application Column
Newcrom AH
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended
Fenofibric acid
HPLC Separation of Fenofibric Acid and Fenofibrate on Primesep 100 Column
September 1, 2021
HPLC Method for Fenofibric acid, Fenofibrate on Primesep 100 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Fenofibric acid, Fenofibrate.
Fenofibric acid is used to treat high levels of cholesterol and triglyceride in blood, which can help prevent pancreatitis. It works through activating peroxisome proliferator-activated receptor alpha. This leads to increased activity lipoprotein lipase and decreased production of proprotein.
Fenofibrate is used to treat high levels of cholesterol and triglyceride in blood, which can help prevent pancreatitis. It works when it is converted into Fenofibric acid, listed above.
Fenofibric acid, Fenofibrate can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a formic acid buffer. Detection is performed using UV.
| Column | Solid-Core Primesep 100, 2.1 x 100 mm, 2.7 µm, 90 A, dual ended |
| Mobile Phase | MeCN – 60% |
| Buffer | Formic Acid – 0.05% |
| Flow Rate | 0.2 ml/min |
| Detection | UV, 286 nm |
| Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, Supplements |
| Analyzing Compounds | Fenofibric acid, Fenofibrate |
Application Column
Solid-Core Primesep 100
Column Diameter: 2.1 mm
Column Length: 100 mm
Particle Size: 2.7 µm
Pore Size: 90 A
Attribute: none
Column options: dual ended
Fenofibric acid
HPLC Method for Analysis of Fenofibric Acid and Fenofibrate on Primesep 200 column
May 10, 2016
Fenofibrate is a synthetic Peroxisome Proliferator Receptor alpha (PPAR alpha) Agonist as well as an antilipemic agent. It is used to help lower “bad” cholesterol and fats (LDL, triglycerides) by increasing the natural enzyme that breaks down fats in the blood. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Propranolol. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
| Column | Primesep 200, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | MeCN – 45% |
| Buffer | H2SO4 – 0.05%, |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 286 nm |
| Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, Supplements |
| Analyzing Compounds | Fenofibrate |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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