Ciclopirox

Ciclopirox structural formula

CAS Number29342-05-0
Molecular FormulaC12H17NO2
Molecular Weight207.273
InChI KeySCKYRAXSEDYPSA-UHFFFAOYSA-N
LogP2.37
Synonyms
  • Ciclopirox
  • 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one
  • 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-
  • 29342-05-0
  • 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-
  • 2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-
  • EINECS 249-577-2
  • Loprox Gel
  • Loprox cream
  • Ciclopirox gel
  • Ciclopiroxum
  • UNII-19W019ZDRJ
  • 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone

Applications:

HPLC Determination of Ciclopirox on Newcrom A Column

July 28, 2020

HPLC Method for Ciclopirox on Newcrom A by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Ciclopirox.

Ciclopirox is a prescription medication with the chemical formula C12H17NO2. It is used to treat topical fungal infections on skin, nails, and scalp. It is available in a variety of forms from shampoo, to nail lacquer, to cream.

Ciclopirox can be retained and analyzed using the Newcrom A stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a perchloric acid buffer. Detection is performed using UV.

Condition
Column Newcrom A, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN – 45%
Buffer HClO4 – 0.2%
Flow Rate 1.0 ml/min
Detection UV 300 nm

Description
Class of Compounds Drug, Synthetic antifungal agent
Analyzing Compounds Ciclopirox

 

Application Column

Newcrom A

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Ciclopirox
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Ciclopirox on Newcrom R1 HPLC column

May 16, 2018
Separation of Ciclopirox on Newcrom R1 HPLC column

Ciclopirox can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ciclopirox
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.