Cannabichromene (CBC)

Cannabichromene (CBC)

CAS Number20675-51-8
Molecular FormulaC21H30O2
Molecular Weight314.5
InChI KeyUVOLYTDXHDXWJU-UHFFFAOYSA-N
LogP6.9
Synonyms
  • CANNABICHROMENE
  • 20675-51-8
  • Cannabichrome
  • Cannanbichromene
  • Pentylcannabichromene
  • Cannabinochromene
  • CHEBI:3357
  • CHEMBL422704
  • UVOLYTDXHDXWJU-UHFFFAOYSA-N
  • 2H-1-Benzopyran-5-ol, 2-methyl-2-(4-methyl-3-pentenyl)-7-pentyl-
  • 2-methyl-2-(4-methylpent-3-enyl)-7-pentylchromen-5-ol
  • Cannabichromene (CBC)
  • 2-methyl-2-(4-methylpent-3-enyl)-7-pentyl-chromen-5-ol
  • 2-Methyl-2-(4-methyl-3-pentenyl)-7-pentyl-2H-1-benzopyran-5-ol
  • Cannabichchromene
  • (+/-)-Cannabichromene
  • (.+/-.)-Cannabichromene
  • SCHEMBL144938
  • DTXSID80942873
  • BDBM50318486
  • NSC291831
  • AKOS032948832
  • NSC-291831
  • 2H-1-Benzopyran-5-ol, (.+-.)-
  • 4CN-2453
  • LS-39404
  • ( inverted exclamation markA)-Cannabichromene
  • C08998
  • Cannabichromene (CBC) 100 microg/mL in Methanol
  • Q410949
  • Cannabichromene (CBC) 1000 microg/mL in Methanol
  • 2-Methyl-2-(4-methyl-3-pentenyl)-7-pentyl-2H-chromen-5-ol
  • 2-Methyl-2-(4-methylpent-3-en-1-yl)-7-pentyl-2H-chromen-5-ol
  • 2-Methyl-2-(4-methylpent-3-en-1-yl)-7-pentyl-2H-1-benzopyran-5-ol
  • 2H-1-Benzopyran-5-ol, 2-methyl-2-(4-methyl-3-penten-1-yl)-7-pentyl-
  • 2-Methyl-2-(4-methyl-pent-3-enyl)-7-pentyl-2H-chromen-5-ol(cannabichromene)

Applications:

HPLC Determination of THC in THC Infused Gummy Bear on Cannsep C Column

January 24, 2020

HPLC Method for Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabidivarin (CBDV), Tetrahydrocannabivarin (THCV), Cannabidiolic acid (CBDA), Cannabigerol (CBG), Cannabinol (CBN), Delta-8-Tetrahydrocannabinol (8-THC), Cannabichromene (CBC), Tetrahydrocannabinolic acid (THCA-A) on Cannsep C by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabidivarin (CBDV), Tetrahydrocannabivarin (THCV), Cannabidiolic acid (CBDA), Cannabigerol (CBG), Cannabinol (CBN), Delta-8-Tetrahydrocannabinol (8-THC), Cannabichromene (CBC), Tetrahydrocannabinolic acid (THCA-A).

Cannabidivarin (CBDV) is a non-intoxicating psychoactive cannabinoid with the chemical formula C19H26O2. Due to it demonstrating anticonvulsive properties, it is actively in Phase-2 trials for adult epilepsy, childhood epilepsy, and for Prader-Willi Syndrome.

Tetrahydrocannabivarin (THCV, THV) is a cannabinoid receptor type 1 antagonist with the chemical formula C19H26O2. It is prevalent in certain strains of Cannabis in central Asia and southern Africa. It is currently being researched as a potential treatment for obesity-associated glucose intolerances. It is also said to reduce appetite and have energizing effects.

Cannabidiol  (CBD) is a phytocannabinoid with the chemical formula C21H30O2. It is used in a variety of ways. It’s only confirmed medical use is as epilepsy medication. It may help with pain, sleep, and addiction as an alternative to opioids, but due to limited clinical evidence, it’s regulations are dependent on the state. It is advised against using it during pregnancy due to unknown effects on fetal and infant development.

Cannabidiolic Acid (CBDA) is a precursor to Cannabidiol with the chemical formula C22H30O4. Research suggests that it might have anti-inflammatory, anti-emetic, anti-convulsant, and anti-carcinogenic properties, but not enough research has been done into it for it to be used as widely as other cannabinoids and the like.

Cannabigerol (CBG) is a non-psychoactive cannabinoid with the chemical formula C21H32O2.  It is a minor constituent of cannabis. CBG that is derrived from marijuana is illegal, while CBG derived from hemp is legal as long as the THC content of hemp is less than 0.3% of dry weight. It was sold illegally by certain companies under unproven claims of being treatment against the COVID-19 virus and inflammation.

Cannabinol (CBN) is a mildly psychoactive phytocannabinoid with the chemical formula C21H26O2. It was the first cannabinoid to be isolated from cannabis in the late 1800s. It is legal in the United States as long as the THC concentration is 0.3% or less.

Delta-8-Tetrahydrocannabinol, also known as delta-8-THC and Δ8-THC, is a sychoactive cannabinoid with the chemical formula C21H30O2. It is less potent than delta-9-THC, it works in a similar way by binding to cannabinoid receptors in the brain. It’s legality is dependent on the state.

Delta-9-Tetrahydrocannabinol, also known as delta-9-THC and Δ9-THC, or simply THC, is the principal psychoactive constituent of Cannabis with the chemical formula C21H30O2. In pharmaceutical contexts, it is referred to as dronabinol and is used un nabiximols, which helps alleviate neuropathic pain, spasticity, overactive bladder, and more. Medical use of THC is allowed in the majority of the states in the United States of America, with less than half having it be legal for recreational use.

Cannabichromene (CBC), also known as cannabichrome, cannanbichromene, pentylcannabichromene and cannabinochromene is a phytocannabinoid with the chemical formula C21H30O2. Research suggests that it might have anti-inflammatory, anti-emetic, anti-convulsant, and anti-carcinogenic properties, but not enough research has been done into it for it to be used as widely as other cannabinoids and the like.

Tetrahydrocannabinolic acid (THCA), also known as conjugate base tetrahydrocannabinolate, is a precursor of Tetrahydrocannabinol with the chemical formula C22H30O4. Findings in regards to it being anything besides the THC precursor are limited, nor is it scheduled at the federal level in the United States, but it may be considered an analog of THC, leading to a risk if possessing or selling it.

Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabidivarin (CBDV), Tetrahydrocannabivarin (THCV), Cannabidiolic acid (CBDA), Cannabigerol (CBG), Cannabinol (CBN), Delta-8-Tetrahydrocannabinol (8-THC), Cannabichromene (CBC), Tetrahydrocannabinolic acid (THCA-A) can be retained and analyzed using the Cannsep C stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using UV.

Condition

Column Cannsep C, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase Gradient MeCN 60-80%, 25 min, 5 min hold
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Drug,  Hydrophilic, Ionizable, Supplements
Analyzing Compounds Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabidivarin (CBDV), Tetrahydrocannabivarin (THCV), Cannabidiolic acid (CBDA), Cannabigerol (CBG), Cannabinol (CBN), Delta-8-Tetrahydrocannabinol (8-THC), Cannabichromene (CBC), Tetrahydrocannabinolic acid (THCA-A)

 

Application Column

Cannsep C

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Cannabichromene (CBC)
Cannabidiol (CBD)
Cannabidiolic acid (CBDA)
Cannabidivarin (CBDV)
Cannabigerol (CBG)
Cannabinol (CBN)
Delta-8-Tetrahydrocannabinol (8-THC)
Delta-9-Tetrahydrocannabinol (THC)
Tetrahydrocannabinol (THC)
Tetrahydrocannabinolic acid (THCA-A)
Tetrahydrocannabivarin (THCV)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Ten Cannabinoids on Cannsep C Column

January 13, 2020

HPLC Method for Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV), Cannabidiol (CBD), Cannabinol (CBN), Cannabichromene (CBC), Cannabidivarin (CBDV), Cannabigerol (CBG), Cannabidiolic acid (CBDA) on Cannsep C by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV), Cannabidiol (CBD), Cannabinol (CBN), Cannabichromene (CBC), Cannabidivarin (CBDV), Cannabigerol (CBG), Cannabidiolic acid (CBDA).

Cannabidivarin (CBDV) is a non-intoxicating psychoactive cannabinoid with the chemical formula C19H26O2. Due to it demonstrating anticonvulsive properties, it is actively in Phase-2 trials for adult epilepsy, childhood epilepsy, and for Prader-Willi Syndrome.

Tetrahydrocannabivarin (THCVTHV) is a cannabinoid receptor type 1 antagonist with the chemical formula C19H26O2. It is prevalent in certain strains of Cannabis in central Asia and southern Africa. It is currently being researched as a potential treatment for obesity-associated glucose intolerances. It is also said to reduce appetite and have energizing effects.

Cannabidiol  (CBD) is a phytocannabinoid with the chemical formula C21H30O2. It is used in a variety of ways. It’s only confirmed medical use is as epilepsy medication. It may help with pain, sleep, and addiction as an alternative to opioids, but due to limited clinical evidence, it’s regulations are dependent on the state. It is advised against using it during pregnancy due to unknown effects on fetal and infant development.

Cannabidiolic Acid (CBDA) is a precursor to Cannabidiol with the chemical formula C22H30O4. Research suggests that it might have anti-inflammatory, anti-emetic, anti-convulsant, and anti-carcinogenic properties, but not enough research has been done into it for it to be used as widely as other cannabinoids and the like.

Cannabigerol (CBG) is a non-psychoactive cannabinoid with the chemical formula C21H32O2.  It is a minor constituent of cannabis. CBG that is derrived from marijuana is illegal, while CBG derived from hemp is legal as long as the THC content of hemp is less than 0.3% of dry weight. It was sold illegally by certain companies under unproven claims of being treatment against the COVID-19 virus and inflammation.

Cannabinol (CBN) is a mildly psychoactive phytocannabinoid with the chemical formula C21H26O2. It was the first cannabinoid to be isolated from cannabis in the late 1800s. It is legal in the United States as long as the THC concentration is 0.3% or less.

Delta-8-Tetrahydrocannabinol, also known as delta-8-THC and Δ8-THC, is a sychoactive cannabinoid with the chemical formula C21H30O2. It is less potent than delta-9-THC, it works in a similar way by binding to cannabinoid receptors in the brain. It’s legality is dependent on the state.

Delta-9-Tetrahydrocannabinol, also known as delta-9-THC and Δ9-THC, or simply THC, is the principal psychoactive constituent of Cannabis with the chemical formula C21H30O2. In pharmaceutical contexts, it is referred to as dronabinol and is used un nabiximols, which helps alleviate neuropathic pain, spasticity, overactive bladder, and more. Medical use of THC is allowed in the majority of the states in the United States of America, with less than half having it be legal for recreational use.

Cannabichromene (CBC), also known as cannabichrome, cannanbichromene, pentylcannabichromene and cannabinochromene is a phytocannabinoid with the chemical formula C21H30O2. Research suggests that it might have anti-inflammatory, anti-emetic, anti-convulsant, and anti-carcinogenic properties, but not enough research has been done into it for it to be used as widely as other cannabinoids and the like.

Tetrahydrocannabinolic acid (THCA), also known as conjugate base tetrahydrocannabinolate, is a precursor of Tetrahydrocannabinol with the chemical formula C22H30O4. Findings in regards to it being anything besides the THC precursor are limited, nor is it scheduled at the federal level in the United States, but it may be considered an analog of THC, leading to a risk if possessing or selling it.

Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV), Cannabidiol (CBD), Cannabinol (CBN), Cannabichromene (CBC), Cannabidivarin (CBDV), Cannabigerol (CBG), Cannabidiolic acid (CBDA) can be retained and analyzed using the Cannsep C stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using UV.

Condition

Column Cannsep C, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase Gradient MeCN 60-80% , 20 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Drug,  Hydrophilic, Ionizable, Supplements
Analyzing Compounds Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV), Cannabidiol (CBD), Cannabinol (CBN), Cannabichromene (CBC), Cannabidivarin (CBDV), Cannabigerol (CBG), Cannabidiolic acid (CBDA)

 

Application Column

Cannsep C

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Cannabichromene (CBC)
Cannabidiol (CBD)
Cannabidiolic acid (CBDA)
Cannabidivarin (CBDV)
Cannabigerol (CBG)
Cannabinol (CBN)
Delta-9-Tetrahydrocannabinol (THC)
Tetrahydrocannabinol (THC)
Tetrahydrocannabinolic acid (THCA-A)
Tetrahydrocannabivarin (THCV)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Ten Cannabinoids on Cannsep B Column

January 13, 2020

HPLC Method for Cannabidiolic acid (CBDA), Cannabidiol (CBD), Cannabidivarin (CBDV), Cannabinol (CBN), Cannabichromene (CBC), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV) on Cannsep B by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Cannabidiolic acid (CBDA), Cannabidiol (CBD), Cannabidivarin (CBDV), Cannabinol (CBN), Cannabichromene (CBC), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV).

Cannabidivarin (CBDV) is a non-intoxicating psychoactive cannabinoid with the chemical formula C19H26O2. Due to it demonstrating anticonvulsive properties, it is actively in Phase-2 trials for adult epilepsy, childhood epilepsy, and for Prader-Willi Syndrome.

Tetrahydrocannabivarin (THCVTHV) is a cannabinoid receptor type 1 antagonist with the chemical formula C19H26O2. It is prevalent in certain strains of Cannabis in central Asia and southern Africa. It is currently being researched as a potential treatment for obesity-associated glucose intolerances. It is also said to reduce appetite and have energizing effects.

Cannabidiol  (CBD) is a phytocannabinoid with the chemical formula C21H30O2. It is used in a variety of ways. It’s only confirmed medical use is as epilepsy medication. It may help with pain, sleep, and addiction as an alternative to opioids, but due to limited clinical evidence, it’s regulations are dependent on the state. It is advised against using it during pregnancy due to unknown effects on fetal and infant development.

Cannabidiolic Acid (CBDA) is a precursor to Cannabidiol with the chemical formula C22H30O4. Research suggests that it might have anti-inflammatory, anti-emetic, anti-convulsant, and anti-carcinogenic properties, but not enough research has been done into it for it to be used as widely as other cannabinoids and the like.

Cannabigerol (CBG) is a non-psychoactive cannabinoid with the chemical formula C21H32O2.  It is a minor constituent of cannabis. CBG that is derrived from marijuana is illegal, while CBG derived from hemp is legal as long as the THC content of hemp is less than 0.3% of dry weight. It was sold illegally by certain companies under unproven claims of being treatment against the COVID-19 virus and inflammation.

Cannabinol (CBN) is a mildly psychoactive phytocannabinoid with the chemical formula C21H26O2. It was the first cannabinoid to be isolated from cannabis in the late 1800s. It is legal in the United States as long as the THC concentration is 0.3% or less.

Delta-8-Tetrahydrocannabinol, also known as delta-8-THC and Δ8-THC, is a sychoactive cannabinoid with the chemical formula C21H30O2. It is less potent than delta-9-THC, it works in a similar way by binding to cannabinoid receptors in the brain. It’s legality is dependent on the state.

Delta-9-Tetrahydrocannabinol, also known as delta-9-THC and Δ9-THC, or simply THC, is the principal psychoactive constituent of Cannabis with the chemical formula C21H30O2. In pharmaceutical contexts, it is referred to as dronabinol and is used un nabiximols, which helps alleviate neuropathic pain, spasticity, overactive bladder, and more. Medical use of THC is allowed in the majority of the states in the United States of America, with less than half having it be legal for recreational use.

Cannabichromene (CBC), also known as cannabichrome, cannanbichromene, pentylcannabichromene and cannabinochromene is a phytocannabinoid with the chemical formula C21H30O2. Research suggests that it might have anti-inflammatory, anti-emetic, anti-convulsant, and anti-carcinogenic properties, but not enough research has been done into it for it to be used as widely as other cannabinoids and the like.

Tetrahydrocannabinolic acid (THCA), also known as conjugate base tetrahydrocannabinolate, is a precursor of Tetrahydrocannabinol with the chemical formula C22H30O4. Findings in regards to it being anything besides the THC precursor are limited, nor is it scheduled at the federal level in the United States, but it may be considered an analog of THC, leading to a risk if possessing or selling it.

Cannabidiolic acid (CBDA), Cannabidiol (CBD), Cannabidivarin (CBDV), Cannabinol (CBN), Cannabichromene (CBC), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV) can be retained and analyzed using the Cannsep B stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using UV.

Condition

Column Cannsep B, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase Gradient MeCN 50-70% , 25 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Drug,  Hydrophilic, Ionizable, Supplements
Analyzing Compounds Cannabidiolic acid (CBDA), Cannabidiol (CBD), Cannabidivarin (CBDV), Cannabinol (CBN), Cannabichromene (CBC), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Delta-9-Tetrahydrocannabinol (THC), Tetrahydrocannabinolic acid (THCA-A), Tetrahydrocannabivarin (THCV)

 

Application Column

Cannsep B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Cannabichromene (CBC)
Cannabidiol (CBD)
Cannabidiolic acid (CBDA)
Cannabidivarin (CBDV)
Cannabigerol (CBG)
Cannabinol (CBN)
Delta-9-Tetrahydrocannabinol (THC)
Tetrahydrocannabinol (THC)
Tetrahydrocannabinolic acid (THCA-A)
Tetrahydrocannabivarin (THCV)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Fast Separation of Cannabinoids on Mixed-Mode HPLC Column Cannsep B

December 5, 2013

With legalization of marijuana in much of the United States, more and more attention is paid to developing quick, robust and reliable method for quantitation of cannabinoids in marijuana plants and related edible products. The main challenge lies in sample preparation and quantitative analysis of four major cannabinoids: cannabidiol, cannabinol, tetrahydrocannabinol and tetrahydrocannabinolic acid. All compounds are hydrophobic with only THCA (THC-A) and cannabidiolic acid (CBDA) being an acid. Hydrophobic interaction is the main interaction in the separation of cannabinoids on reverse phase columns. On our mixed mode columns acidic molecules retained by ion-exchange mechanism  in addition to hydrophobic. Method can be used for analysis and prep separation of cannabinoids in marijuana plants, seeds and other cannabis-based products. Extraction of cannabinoids is the main procedure in sample preparation. Extraction can be done with organic solvents like chloroform, methanol, ethanol, acetonitrile.  Cannabinoids can be monitored by UV and LC/MS. Mixed-mode columns containing polar embedded groups provide different selectivity than regular reversed-phase columns.

 

Condition

Column Cannsep B, 4.6×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN 40-60% , 20 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Drug,  Hydrophilic, Ionizable, Supplements
Analyzing Compounds Cannabidivarin (CBDV), Tetrahydrocannabivarin (THCV), Cannabidiol (CBD) Delta-9-Tetrahydrocannabinol (THC), Cannabigerol (CBG), Cannabichromene (CBC), Tetrahydrocannabinolic acid (THCA-A)

 

Application Column

Cannsep B

The Cannsep family of columns is a specially developed line of reverse-phase columns designed to retain and separate most of the compounds responsible for cannabis's physiological properties. With three options available - Cannsep A, Cannsep B, and Cannsep C - customers can resolve all the various cannabinoids, each providing unique and significantly orthogonal selectivity.

Select options
Application Analytes:
Cannabichromene (CBC)
Cannabidiol (CBD)
Cannabidivarin (CBDV)
Cannabigerol (CBG)
Cannabinol (CBN)
Tetrahydrocannabinol (THC)
Tetrahydrocannabinolic acid (THCA-A)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.