Dibazol (Bendazol)

Bendazol [INN:DCF] structural formula

CAS Number621-72-7
Molecular FormulaC14H12N2
Molecular Weight208.265
InChI KeyYTLQFZVCLXFFRK-UHFFFAOYSA-N
LogP3.23
Synonyms
  • Bendazol [INN:DCF]
  • 2-Benzyl-1H-benzimidazole
  • 1H-Benzimidazole, 2-(phenylmethyl)-
  • 621-72-7
  • 5-23-08-00498
  • 2-Benzylbenziminazole
  • BRN 0159495
  • Dibasol
  • Dibazol
  • Dibazole
  • EINECS 210-703-6
  • NSC 60020
  • 2-(Phenylmethyl)-1H-benzimidazole
  • Tromasedan
  • Bendazolo
  • Bendazolum
  • UNII-26601THN1D

Applications:

Separation of Dibazol (Bendazol) and Papaverine in Papazol Tablets on Newcrom BH Column

October 21, 2020

HPLC Method for Papaverine, Dibazol (Bendazol), Papaverine hydrochloride on Newcrom BH by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Papaverine, Dibazol (Bendazol), Papaverine hydrochloride.

Dibazol, also known as Bendazol, is a vasodilator and antispasmodic medication with the chemical formula C14H12N2. It is used primarily to treat hypertension and muscle spasms. It is not approved for use in the United States of America, and is typically prescribed in other countries.

Papaverine is an opium alkaloid antispasmodic drug with the chemical formula C20H21NO4. It is typically used to treat erectile dysfunction, improve blood flow, and relax smooth muscles.

Papaverine, Dibazol (Bendazol), Papaverine hydrochloride can be retained and analyzed using the Newcrom BH stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a perchloric acid buffer. Detection is performed using UV.

Condition
Column Newcrom BH, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 15/85%
Buffer HClO4 – 0.3%
Flow Rate 1.0 ml/min
Detection UV 265 nm

Description
Class of Compounds Drug
Analyzing Compounds Papaverine, Dibazol (Bendazol), Papaverine hydrochloride

 

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Dibazol (Bendazol)
Papaverine
Papaverine hydrochloride
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Bendazol [INN:DCF] on Newcrom R1 HPLC column

May 16, 2018
Separation of Bendazol [INN:DCF] on Newcrom R1 HPLC column

Bendazol [INN:DCF] can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Dibazol (Bendazol)
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.