| Molecular Formula | C6H10O4 or HOOC(CH2)4COOH |
|---|---|
| Molecular Weight | 146.14 |
| InChI Key | WNLRTRBMVRJNCN-UHFFFAOYSA-N |
| LogP | 0.1 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Dibasic Acids on Newcrom B Column
July 29, 2022
HPLC Method for Adipic Acid, Succinic Acid, Glutaric acid, Methylmalonic Acid on Newcrom B by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Adipic Acid, Succinic Acid, Glutaric acid, Methylmalonic Acid.
Succinic acid is a key intermediary (in the form of its anion, succinate) in the electron transport chain, a process that is the key power source for our cells. It also has a few limited functions outside of the mitochondria. It has the chemical formula C4H6O4.
Glutaric acid is a common plasticizer precursor with the chemical formula C5H8O4. It is often used in the production of polyester polyols and polyamides. Interestingly, it is significantly more water soluble than either Succinic or Adipic acid.
Adipic acid, also known as hexanedioic acid, is a key precursor to nylon, and more than 2.5 billion kilograms are produced every year. In medicinal uses, it has been incorporated into controlled-release formulation as well as the polymeric coating of hydrophilic monolithic systems. It has the chemical formula C6H10O4.
Methylmalonic Acid is an organic acid with the chemical formula C4H6O4. It works as an intermediate in the breakdown of certain amino acids and fatty acids. Elevated levels of Methylmalonic acid can be a sign of a Vitamin B12 deficiency or Methylmalonic acidemia, which is a rare genetic disorder where the previously mentioned acid is not properly metabolized.
Adipic Acid, Succinic Acid, Glutaric acid, Methylmalonic Acid can be separated, retained, and analyzed on a mixed-mode Newcrom B column with a mobile phase consisting of water, Acetonitrile (MeCN), and Sulfuric acid (FA). This analytical method can be UV detected at 200 nm with high resolution and peak symmetry.
| Column | Newcrom B, 4.6 x 150 mm, 3 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O -5/95% |
| Buffer | H2SO4 – 0.02% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 200 nm |
| Class of Compounds | Acid, Hydrophilic |
| Analyzing Compounds | Adipic Acid, Succinic Acid, Glutaric acid, Methylmalonic Acid |
Application Column
Newcrom B
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended
Glutaric acid
Methylmalonic Acid
Succinic Acid
HPLC Method for Analysis of Adipic Acid on Newcrom B Column
July 28, 2022
HPLC Method for Adipic Acid on Newcrom B by SIELC Technologies
Separation type: Liquid Chromatography Mixed-mode
High Performance Liquid Chromatography (HPLC) Method for Analysis of Adipic Acid
Adipic acid (or Hexanedioic acid) is a heavily used, industrial dicarboxylic acid used as a pre-cursor for the mass-production of nylon. It is also used as an ingredient in timed-release drug capsules and as a tart flavoring agent in foods. Adipic acid can be retained and analyzed on a mixed-mode Newcrom B column with a mobile phase consisting of water, Acetonitrile (MeCN), and Sulfuric acid (H2SO4). This analytical method can be UV detected at 200 nm with high resolution and peak symmetry.
| Column | Newcrom B, 4.6 x 150 mm, 3 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O -5/95% |
| Buffer | H2SO4 – 0.02% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 200 nm |
| Class of Compounds | Acid, Hydrophilic |
| Analyzing Compounds | Adipic Acid |
Application Column
Newcrom B
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended
