Quetiapine

CAS Number111974-69-7
Molecular FormulaC21H25N3O2S
Molecular Weight383.511
InChI KeyURKOMYMAXPYINW-UHFFFAOYSA-N
LogP2.09
Synonyms
  • Quetiapine
  • 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy}ethan-1-ol
  • Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-
  • 111974-69-7
  • Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-
  • UNII-BGL0JSY5SI
  • Co-Quetiapine
  • 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
  • 2-[2-(4-{2-thia-9-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol
  • Quetiapine
  • Quetiapine fumarate
  • Seroquel

Applications:

Uv-Vis Spectrum of Quetiapine

February 17, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Quetiapine check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Quetiapine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Quetiapine in Tablets on Newcrom R1 Column

June 7, 2018

HPLC Method for Quetiapine on Newcrom R1 by SIELC Technologies

HPLC Method for Analysis of Quetiapine in Tablets_Chr_1134

High Performance Liquid Chromatography (HPLC) Method for Analysis of Quetiapine 

Quetiapine is an antipsychotic medication with the molecular formula of C21H25N3O2S • 1/2C4H4O4. It is only available through prescription to treat a variety of mental health disorders. It blocks neurotransmitters in the brain, and by altering levels of the chemicals produced, it can help regulate behavior.

Quetiapine can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a Triethanolamine buffer. Detection is performed using UV.

ColumnNewcrom R1, 4.6 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 20/80%
BufferTEAPh – 50 mM
Flow Rate1.0 ml/min
DetectionUV, 250 nm
Class of Compounds
Drug, Antipsychotic, Hydrophobic, Neutral
Analyzing CompoundsQuetiapine

Application Column

Newcrom R1

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Quetiapine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.