Perindopril

Perindopril structural formula

CAS Number82834-16-0
Molecular FormulaC19H32N2O5
Molecular Weight368.474
InChI KeyIPVQLZZIHOAWMC-QXKUPLGCSA-N
LogP2.13
Synonyms
  • Perindopril
  • (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name)
  • 82834-16-0
  • BRN 4300272
  • Perindoprilum
  • UNII-Y5GMK36KGY
  • (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid

Applications:

HPLC Determination of Perindopril on Primesep 200 column

June 14, 2019

HPLC Determination of Perindopril

Perindopril is an ACE inhibitor used in treating hypertension (high blood pressure). It comes in tablet form. Perindopril can be retained on a Primesep 200 column in under 8 minutes with a simple isocratic mobile phase and sulphuric acid buffer. Primesep 200 is a reverse-phase (RP) mixed-mode column with embedded weak acidic ion-pairing groups

 

Condition

Column Primesep 200, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 20/80%
Buffer H2SO4 – 0.4 %
Flow Rate 1.0 ml/min
Detection UV, 205 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophobic, Ionizable
Analyzing Compounds Perindopril

 

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Perindopril
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Perindopril on Newcrom R1 HPLC column

February 16, 2018
Separation of Perindopril on Newcrom C18 HPLC column

Perindopril can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Perindopril
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.