| CAS Number | 82834-16-0 |
|---|---|
| Molecular Formula | C19H32N2O5 |
| Molecular Weight | 368.474 |
| InChI Key | IPVQLZZIHOAWMC-QXKUPLGCSA-N |
| LogP | 2.13 |
| Synonyms |
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Applications:
HPLC Determination of Perindopril on Primesep 200 column
June 14, 2019
Perindopril is an ACE inhibitor used in treating hypertension (high blood pressure). It comes in tablet form. Perindopril can be retained on a Primesep 200 column in under 8 minutes with a simple isocratic mobile phase and sulphuric acid buffer. Primesep 200 is a reverse-phase (RP) mixed-mode column with embedded weak acidic ion-pairing groups
Condition
Column Primesep 200, 4.6×150 mm, 5 µm, 100A Mobile Phase MeCN/H2O – 20/80% Buffer H2SO4 – 0.4 % Flow Rate 1.0 ml/min Detection UV, 205 nm
Description
Class of Compounds
Drug, Acid, Hydrophobic, Ionizable Analyzing Compounds Perindopril
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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Separation of Perindopril on Newcrom R1 HPLC column
February 16, 2018
Perindopril can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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