| CAS Number | 82834-16-0 |
|---|---|
| Molecular Formula | C19H32N2O5 |
| Molecular Weight | 368.474 |
| InChI Key | IPVQLZZIHOAWMC-QXKUPLGCSA-N |
| LogP | 2.13 |
| Synonyms |
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Applications:
HPLC Determination of Perindopril on Primesep 200 column
June 14, 2019
HPLC Method for Perindopril on Primesep 200 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Perindopril.
Perindopril is an ACE inhibitor used in treating hypertension (high blood pressure). It comes in tablet form. Perindopril can be retained on a Primesep 200 column in under 8 minutes with a simple isocratic mobile phase and sulphuric acid buffer. Primesep 200 is a reverse-phase (RP) mixed-mode column with embedded weak acidic ion-pairing groups
Condition
Column Primesep 200 Mobile Phase MeCN/H2O – 20/80% Buffer H2SO4 – 0.4 % Flow Rate 1.0 ml/min Detection UV, 205 nm
Description
Class of Compounds
Drug, Acid, Hydrophobic, Ionizable Analyzing Compounds Perindopril
Application Column
Primesep 200
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Separation of Perindopril on Newcrom R1 HPLC column
February 16, 2018
Perindopril can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select options
