HPLC Determination of Perindopril on Primesep 200 column

HPLC Determination of Perindopril
Perindopril is an ACE inhibitor used in treating hypertension (high blood pressure). It comes in tablet form. Perindopril can be retained on a Primesep 200 column in under 8 minutes with a simple isocratic mobile phase and sulphuric acid buffer. Primesep 200 is a reverse-phase (RP) mixed-mode column with embedded weak acidic ion-pairing groups


Column Primesep 200, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer H2SO4 - 0.4 %
Flow Rate 1.0 ml/min
Detection UV, 205 nm


Class of Compounds Drug, Acid, Hydrophobic, Ionizable
Analyzing Compounds Perindopril

Application Analytes: