| CAS Number | 3731-59-7 |
|---|---|
| Molecular Formula | C6H13N5O |
| Molecular Weight | 171.20 |
| InChI Key | KJHOZAZQWVKILO-UHFFFAOYSA-N |
| LogP | -1.6 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Moroxydine on Primesep 100 Column
February 1, 2024
High Performance Liquid Chromatography (HPLC) Method for Analysis of Moroxydine on Primesep 100 by SIELC Technologies
Separation type: Liquid Chromatography Mixed-mode SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Moroxydine
Biguanides, including Moroxydine, Metformin, Proguanil, and Phenformin, are a group of organic compounds that share a common structural feature, namely the presence of two guanidine groups.
Moroxydine:
- Moroxydine is an antiviral medication used in the treatment of influenza. It is believed to inhibit the early stages of viral replication.
These biguanides exhibit various pharmacological activities, and while some are primarily used for antidiabetic purposes, others have applications in antiviral or antimalarial treatments. It’s important to note that the safety and efficacy of these drugs depend on proper medical supervision and adherence to prescribed dosages.
Moroxydine can be retained and analyzed using a Primesep 100 mixed-mode stationary phase column. The analysis employs an isocratic method with a simple mobile phase comprising water, acetonitrile (MeCN), and ammonium formate as a buffer. This method allows for detection using UV at 240 nm
| Column | Primesep 100, 4.6 x 150 mm, 5 µm, 100 A |
| Mobile Phase | MeCN/H2O 75/25% |
| Buffer | AmFm pH 3.0 – 30 mM |
| Flow Rate | 1.0 ml/min |
| Detection | UV 240 nm |
| Samples | 0.5 mg/ml |
| Injection volume | 2 µl |
| LOD* | 8 ppb |
| Class of Compounds | Biguanides |
| Analyzing Compounds | Moroxydine |
Application Column
Primesep 100
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
HPLC Method for Separation Biguanides such as Moroxydine, Metformin, Proguanil and Phenformin on Primesep 100 Column
February 1, 2024
High Performance Liquid Chromatography (HPLC) Method for Analysis of Moroxydine, Metformin, Proguanil and Phenformin on Primesep 100 by SIELC Technologies
Separation type: Liquid Chromatography Mixed-mode SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Moroxydine , Metformin, Proguanil and Phenformin
Biguanides, including Moroxydine, Metformin, Proguanil, and Phenformin, are a group of organic compounds that share a common structural feature, namely the presence of two guanidine groups.
Moroxydine:
- Moroxydine is an antiviral medication used in the treatment of influenza. It is believed to inhibit the early stages of viral replication.
Metformin:
- Metformin is an oral antidiabetic medication used to treat type 2 diabetes. It works by reducing glucose production in the liver and improving insulin sensitivity in peripheral tissues. Metformin is one of the most widely prescribed drugs for diabetes management.
Proguanil:
- Proguanil is an antimalarial medication often used in combination with other drugs, such as atovaquone. It is used for both prevention and treatment of malaria. Proguanil is a prodrug, and its active form inhibits the development of the malaria parasite in the liver.
Phenformin:
- Phenformin is an antidiabetic biguanide that was previously used to treat type 2 diabetes. However, due to the risk of lactic acidosis (a serious side effect), it has been largely withdrawn from the market in many countries.
These biguanides exhibit various pharmacological activities, and while some are primarily used for antidiabetic purposes, others have applications in antiviral or antimalarial treatments. It’s important to note that the safety and efficacy of these drugs depend on proper medical supervision and adherence to prescribed dosages.
Biguanides such as Moroxydine , Metformin, Proguanil and Phenformin be retained, separated and analyzed using a Primesep 100 mixed-mode stationary phase column. The analysis employs an isocratic method with a simple mobile phase comprising water, acetonitrile (MeCN), and ammonium formate as a buffer. This method allows for detection using UV at 240 nm
| Column | Primesep 100, 4.6 x 150 mm, 5 µm, 100 A |
| Mobile Phase | MeCN/H2O 70/30% |
| Buffer | AmFm pH 3.0 – 30 mM |
| Flow Rate | 1.0 ml/min |
| Detection | UV 240 nm |
| Samples | 1. 0.1 mg/ml 2. 0.1 mg/ml 3. 0.1 mg/ml 4. 0.1 mg/ml |
| Injection volume | 10 µl |
| LOD* | 1. 7 ppb 2. 7 ppb 3. 17 ppb 4. 18 ppb |
| Class of Compounds | Biguanides |
| Analyzing Compounds | Metformin, Proguanil hydrochloride, Phenformin, Moroxydine |
Application Column
Primesep 100
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Moroxydine
Phenformin
Proguanil hydrochloride
