Melanotan-II

CAS Number121062-08-6
Molecular FormulaC50H69N15O9
Molecular Weight1024.2
InChI KeyJDKLPDJLXHXHNV-MFVUMRCOSA-N
Synonyms
  • Melanotan II
  • 121062-08-6
  • Melanotan-II
  • UPF5CJ93X7
  • DTXSID90153135
  • L-Lysinamide, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2-7)-peptide
  • RefChem:925444
  • DTXCID3075626
  • MT-II
  • Melanotan (MT)-II
  • Melatonan
  • CHEMBL430239
  • (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
  • Melanotan II acetate salt
  • C50H69N15O9
  • (3S,6S,9R,12S,15S,23S)-12-((1H-imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((S)-2-acetamidohexanamido)-9-benzyl-6-(3-guanidinopropyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide
  • MTII
  • MelanotanII
  • Melanotan II?
  • Ac-Nle-Cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
  • UNII-UPF5CJ93X7
  • MELANOTAN II [WHO-DD]
  • ebi_340792
  • GTPL1323
  • orb1296657
  • SCHEMBL1047531
  • SCHEMBL29473785
  • CHEBI:195326
  • EX-A7394
  • HY-P0267
  • BDBM50027084
  • BDBM50184359
  • MFCD06795842
  • AKOS015994654
  • HS-2017
  • NCGC00167281-01
  • DA-55328
  • FA109114
  • M1650
  • F93947
  • Q423855
  • Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-alpha-MSH (4-10) amide
  • (3S,6S,9R,12S,15S,23S)-12-((1H-imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((S)-2-acetamidohexanamido)-9-benzyl-6-(3-((diaminomethylene)amino)propyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide
  • (3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexanoylamino)-9-benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18hexaaza-cyclotricosane-23-carboxylic acid amide
  • (3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-[(1H-imidazol-5-yl)methyl]-3-[(1H-indol-3-yl)methyl]-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide
  • (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-(3-guanidinopropyl)-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
  • (3S,6S,9R,12S,15S,23S)-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-15-[(2S)-2-acetamidohexanamido]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide
  • L-LYSINAMIDE, N-ACETYL-L-NORLEUCYL-L-.ALPHA.-ASPARTYL-L-HISTIDYL-D-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-, CYCLIC (2->7)-PEPTIDE

Applications:

HPLC Method for Analysis of Melanotan 1 and Melanotan 2 on Chromni Column

July 23, 2026

HPLC Method for Melanotan-I, Melanotan-II on Chromni by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Melanotan-I, Melanotan-II

Melanotan-I is a synthetic analogue of a-melanocyte-stimulating hormone (a-MSH) with the chemical formula C78H111N21O19. It is used primarily to provide photoprotection against UV radiation as well as for patients with erythropoietic protoporphyria to increase pain-free light exposure. It is used “off-label” as a synthetic tanner, for which it is not FDA approved.

Melanotan-II is a synthetic analogue of peptide hormone a-a-melanocyte-stimulating hormone (a-MSH) with the chemical formula C50H69N15O9. It is approved by the FDA to treat sun sensitivity, but unlicense Melanotan II is sold as a tanning agent, though health agencies advise against it due to reports of it being a health risk. It works as a non-selective agonist of the melanocortin receptors.

Melanotan-I, Melanotan-II can be retained and analyzed using the Chromni stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) with an sulfuric acid as a buffer. Detection is performed using UV.

ColumnChromni, 4.6 x 150 mm, 3 µm, 100 A, surface coated
Mobile PhaseGradient MeCN – 80 – 60%, 10 min
BufferH2SO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 200 nm, 280 nm
Class of Compounds
 Analogue
Analyzing CompoundsMelanotan-I, Melanotan-II

Application Column

Chromni

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: surface coated

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Application Analytes:
Melanotan-I
Melanotan-II
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.