Losartan

Losartan structural formula

CAS Number114798-26-4
Molecular FormulaC22H23ClN6O
Molecular Weight422.921
InChI KeyPSIFNNKUMBGKDQ-UHFFFAOYSA-N
LogP3.64
Synonyms
  • Losartan
  • (2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
  • 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • 114798-26-4
  • 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • UNII-JMS50MPO89
  • 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
  • (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
  • 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole

Applications:

HPLC Method for Analysis of Losartan on Newcrom R1 Column

January 23, 2024

HPLC Method for Analysis of Losartan on Newcrom R1 Column by SIELC Technologies

Separation type: Liquid Chromatography Reversed-phase

HPLC Method for Analysis of Losartan on Newcrom R1 Column by SIELC Technologies

Losartan is a medication that belongs to a class of drugs known as angiotensin II receptor blockers (ARBs).

  • Losartan is primarily used to treat high blood pressure (hypertension) and certain other conditions related to the heart.
  • It works by blocking the action of angiotensin II, a substance in the body that narrows blood vessels and releases hormones that can raise blood pressure.

Losartan can be retained, and analyzed on a reversed-phase Newcrom R1 column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid. This analytical method can be detected with high resolution and peak symmetry at a wavelength of 200 nm using UV detection

High Performance Liquid Chromatography (HPLC) Method for Analyses of Losartan on Newcrom R1 Column by SIELC Technologies

Condition

ColumnNewcrom R1, 3.2 x 100 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 30/70%,
BufferH2SO4 – 0.1%
Flow Rate0.5 ml/min
DetectionUV 200 nm

Description

Class of CompoundsDiphenyl ethers
Analyzing CompoundsLosartan

Application Column

Newcrom R1

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Losartan
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Losartan on Newcrom R1 HPLC column

February 19, 2018
Separation of Losartan on Newcrom C18 HPLC column

Losartan can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Losartan
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.